The development of RAPTA compounds for the treatment of tumors

Benjamin S. Murray; Maria V. Babak; Christian G. Hartinger; Paul J. Dyson

doi:10.1016/j.ccr.2015.06.014

Author(s)

Benjamin S. Murray
Maria V. Babak
Christian G. Hartinger
Paul J. Dyson

Detail(s)

Original language	English
Pages (from-to)	86-114
Journal / Publication	Coordination Chemistry Reviews
Volume	306
Issue number	1
Online published	7 Jul 2015
Publication status	Published - 1 Jan 2016
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1016/j.ccr.2015.06.014 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-84982077068&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(3dc32fb3-72ed-430d-ac35-e0540ade8536).html

Abstract

Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties. Herein a comprehensive review of this class of compounds is provided. A discussion of the basic RAPTA structure is given together with the ways it has been modified to elucidate the key role of each part and to afford targeted derivatives. The various mechanistic studies conducted on RAPTA compounds are described and these are linked to the observed macroscopic biological properties. Ultimately, the review shows that certain RAPTA compounds display quite unique properties that point towards a clinical investigation.

Research Area(s)

Angiogenesis, Bioorganometallic chemistry, Cancer, Metastasis, RAPTA

Citation Format(s)

[ RIS ] [ BibTeX ]

The development of RAPTA compounds for the treatment of tumors. / Murray, Benjamin S.; Babak, Maria V.; Hartinger, Christian G. et al.
In: Coordination Chemistry Reviews, Vol. 306, No. 1, 01.01.2016, p. 86-114.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Murray, BS, Babak, MV, Hartinger, CG & Dyson, PJ 2016, 'The development of RAPTA compounds for the treatment of tumors', Coordination Chemistry Reviews, vol. 306, no. 1, pp. 86-114. https://doi.org/10.1016/j.ccr.2015.06.014

Murray, B. S., Babak, M. V., Hartinger, C. G., & Dyson, P. J. (2016). The development of RAPTA compounds for the treatment of tumors. Coordination Chemistry Reviews, 306(1), 86-114. https://doi.org/10.1016/j.ccr.2015.06.014

Murray BS, Babak MV, Hartinger CG, Dyson PJ. The development of RAPTA compounds for the treatment of tumors. Coordination Chemistry Reviews. 2016 Jan 1;306(1):86-114. Epub 2015 Jul 7. doi: 10.1016/j.ccr.2015.06.014

Murray, Benjamin S. ; Babak, Maria V. ; Hartinger, Christian G. et al. / The development of RAPTA compounds for the treatment of tumors. In: Coordination Chemistry Reviews. 2016 ; Vol. 306, No. 1. pp. 86-114.