The DermoCytoscope: A Breakthrough Application Specific EndoCytoscope (ASEC) for Affordable and Portable Skin Cancer Diagnostics

Chengshui Chen; Lefu Chen; Yuting Zhang; Yuting Lin; Jiaru Shi; Jianhong Zhang; Yihong Wu; Lingyan Shen; Hongkun Li; FengQing Sun; Yang Yang Li

doi:10.1117/12.3054181

The DermoCytoscope: A Breakthrough Application Specific EndoCytoscope (ASEC) for Affordable and Portable Skin Cancer Diagnostics

Chengshui Chen
, Lefu Chen
, Yuting Zhang
, Yuting Lin
, Jiaru Shi
, Jianhong Zhang
, Yihong Wu
, Lingyan Shen
, Hongkun Li
, FengQing Sun
, Yang Yang Li

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

Abstract

Early diagnosis of skin cancer is crucial for patient prognosis, but traditional diagnostic tools such as dermatoscopy and histopathology have limitations in capturing early microscopic pathological changes. To address this issue, we have developed a high magnification skin microscopy endoscope-DermoCytoscope for precise observation of skin surface and sub surface structures, as well as real-time monitoring of cellular dynamic changes. This study used this DermoCytoscope to observe moles in clinical patients and performed pathological examination after surgical resection. The results indicate that the device can clearly present subtle features of lesions, which are highly consistent with pathological results, demonstrating its potential application in the detection of early skin cancer and pigmented lesions. © 2025 SPIE.

Original language	English
Title of host publication	Optical Diagnostics and Sensing XXV
Subtitle of host publication	Toward Point-of-Care Diagnostics
Editors	Gerard L. Coté, Justin S. Baba
Publisher	SPIE - International Society for Optical Engineering
ISBN (Electronic)	9781510683815
ISBN (Print)	9781510683808
DOIs	https://doi.org/10.1117/12.3054181
Publication status	Published - 20 Mar 2025
Event	SPIE Photonics West 2025: Ultra-High-Definition Imaging Systems VIV Conference - San Francisco, United States Duration: 25 Jan 2025 → 30 Jan 2025

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	13316
ISSN (Print)	1605-7422
ISSN (Electronic)	2410-9045

Conference

Conference	SPIE Photonics West 2025
Place	United States
City	San Francisco
Period	25/01/25 → 30/01/25

Bibliographical note

Full text of this publication does not contain sufficient affiliation information. With consent from the author(s) concerned, the Research Unit(s) information for this record is based on the existing academic department affiliation of the author(s).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

affordable
Compact
DermoCytoscope
Dermoscope
EndoCytoscope
Skin cancer

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10.1117/12.3054181

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Chen, C., Chen, L., Zhang, Y., Lin, Y., Shi, J., Zhang, J., Wu, Y., Shen, L., Li, H., Sun, F., & Li, Y. Y. (2025). The DermoCytoscope: A Breakthrough Application Specific EndoCytoscope (ASEC) for Affordable and Portable Skin Cancer Diagnostics. In G. L. Coté, & J. S. Baba (Eds.), Optical Diagnostics and Sensing XXV: Toward Point-of-Care Diagnostics Article 133160L (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 13316). SPIE - International Society for Optical Engineering. https://doi.org/10.1117/12.3054181

Chen, Chengshui ; Chen, Lefu ; Zhang, Yuting et al. / The DermoCytoscope : A Breakthrough Application Specific EndoCytoscope (ASEC) for Affordable and Portable Skin Cancer Diagnostics. Optical Diagnostics and Sensing XXV: Toward Point-of-Care Diagnostics. editor / Gerard L. Coté ; Justin S. Baba. SPIE - International Society for Optical Engineering, 2025. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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title = "The DermoCytoscope: A Breakthrough Application Specific EndoCytoscope (ASEC) for Affordable and Portable Skin Cancer Diagnostics",

abstract = "Early diagnosis of skin cancer is crucial for patient prognosis, but traditional diagnostic tools such as dermatoscopy and histopathology have limitations in capturing early microscopic pathological changes. To address this issue, we have developed a high magnification skin microscopy endoscope-DermoCytoscope for precise observation of skin surface and sub surface structures, as well as real-time monitoring of cellular dynamic changes. This study used this DermoCytoscope to observe moles in clinical patients and performed pathological examination after surgical resection. The results indicate that the device can clearly present subtle features of lesions, which are highly consistent with pathological results, demonstrating its potential application in the detection of early skin cancer and pigmented lesions. {\textcopyright} 2025 SPIE.",

keywords = "affordable, Compact, DermoCytoscope, Dermoscope, EndoCytoscope, Skin cancer",

author = "Chengshui Chen and Lefu Chen and Yuting Zhang and Yuting Lin and Jiaru Shi and Jianhong Zhang and Yihong Wu and Lingyan Shen and Hongkun Li and FengQing Sun and Li, \{Yang Yang\}",

note = "Full text of this publication does not contain sufficient affiliation information. With consent from the author(s) concerned, the Research Unit(s) information for this record is based on the existing academic department affiliation of the author(s).; SPIE Photonics West 2025 : Ultra-High-Definition Imaging Systems VIV Conference ; Conference date: 25-01-2025 Through 30-01-2025",

year = "2025",

month = mar,

day = "20",

doi = "10.1117/12.3054181",

language = "English",

isbn = "9781510683808",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE - International Society for Optical Engineering",

editor = "Cot{\'e}, \{Gerard L.\} and Baba, \{Justin S.\}",

booktitle = "Optical Diagnostics and Sensing XXV",

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}

Chen, C, Chen, L, Zhang, Y, Lin, Y, Shi, J, Zhang, J, Wu, Y, Shen, L, Li, H, Sun, F & Li, YY 2025, The DermoCytoscope: A Breakthrough Application Specific EndoCytoscope (ASEC) for Affordable and Portable Skin Cancer Diagnostics. in GL Coté & JS Baba (eds), Optical Diagnostics and Sensing XXV: Toward Point-of-Care Diagnostics., 133160L, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 13316, SPIE - International Society for Optical Engineering, SPIE Photonics West 2025, San Francisco, United States, 25/01/25. https://doi.org/10.1117/12.3054181

The DermoCytoscope: A Breakthrough Application Specific EndoCytoscope (ASEC) for Affordable and Portable Skin Cancer Diagnostics. / Chen, Chengshui; Chen, Lefu; Zhang, Yuting et al.
Optical Diagnostics and Sensing XXV: Toward Point-of-Care Diagnostics. ed. / Gerard L. Coté; Justin S. Baba. SPIE - International Society for Optical Engineering, 2025. 133160L (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 13316).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - The DermoCytoscope

T2 - SPIE Photonics West 2025

AU - Chen, Chengshui

AU - Chen, Lefu

AU - Zhang, Yuting

AU - Lin, Yuting

AU - Shi, Jiaru

AU - Zhang, Jianhong

AU - Wu, Yihong

AU - Shen, Lingyan

AU - Li, Hongkun

AU - Sun, FengQing

AU - Li, Yang Yang

N1 - Full text of this publication does not contain sufficient affiliation information. With consent from the author(s) concerned, the Research Unit(s) information for this record is based on the existing academic department affiliation of the author(s).

PY - 2025/3/20

Y1 - 2025/3/20

N2 - Early diagnosis of skin cancer is crucial for patient prognosis, but traditional diagnostic tools such as dermatoscopy and histopathology have limitations in capturing early microscopic pathological changes. To address this issue, we have developed a high magnification skin microscopy endoscope-DermoCytoscope for precise observation of skin surface and sub surface structures, as well as real-time monitoring of cellular dynamic changes. This study used this DermoCytoscope to observe moles in clinical patients and performed pathological examination after surgical resection. The results indicate that the device can clearly present subtle features of lesions, which are highly consistent with pathological results, demonstrating its potential application in the detection of early skin cancer and pigmented lesions. © 2025 SPIE.

AB - Early diagnosis of skin cancer is crucial for patient prognosis, but traditional diagnostic tools such as dermatoscopy and histopathology have limitations in capturing early microscopic pathological changes. To address this issue, we have developed a high magnification skin microscopy endoscope-DermoCytoscope for precise observation of skin surface and sub surface structures, as well as real-time monitoring of cellular dynamic changes. This study used this DermoCytoscope to observe moles in clinical patients and performed pathological examination after surgical resection. The results indicate that the device can clearly present subtle features of lesions, which are highly consistent with pathological results, demonstrating its potential application in the detection of early skin cancer and pigmented lesions. © 2025 SPIE.

KW - affordable

KW - Compact

KW - DermoCytoscope

KW - Dermoscope

KW - EndoCytoscope

KW - Skin cancer

UR - https://www.scopus.com/pages/publications/105004297006

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-105004297006&origin=recordpage

U2 - 10.1117/12.3054181

DO - 10.1117/12.3054181

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781510683808

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Optical Diagnostics and Sensing XXV

A2 - Coté, Gerard L.

A2 - Baba, Justin S.

PB - SPIE - International Society for Optical Engineering

Y2 - 25 January 2025 through 30 January 2025

ER -

Chen C, Chen L, Zhang Y, Lin Y, Shi J, Zhang J et al. The DermoCytoscope: A Breakthrough Application Specific EndoCytoscope (ASEC) for Affordable and Portable Skin Cancer Diagnostics. In Coté GL, Baba JS, editors, Optical Diagnostics and Sensing XXV: Toward Point-of-Care Diagnostics. SPIE - International Society for Optical Engineering. 2025. 133160L. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.3054181

The DermoCytoscope: A Breakthrough Application Specific EndoCytoscope (ASEC) for Affordable and Portable Skin Cancer Diagnostics

Abstract

Publication series

Conference

Bibliographical note

UN SDGs

Research Keywords

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