The comprehensive and systematic identification of BLCA-specific SF-regulated, survival-related AS events

Zhe Liu; Xudong Liu; Fang Liu; Hui Zhao; Yu Zhang; Yafan Wang; Ying Ma; Fuzhou Wang; Weitong Zhang; Olutomilayo Olayemi Petinrin; Zhongyu Yao; Jingbo Liang; Qian He; Dayun Feng; Lei Wang; Ka-Chun Wong

doi:10.1016/j.gene.2022.146657

Author(s)

Xudong Liu
Fang Liu
Hui Zhao
Yu Zhang
Yafan Wang
Ying Ma
Jingbo Liang
Qian He
Dayun Feng
Lei Wang
Ka-Chun Wong

Related Research Unit(s)

Detail(s)

Original language	English
Article number	146657
Journal / Publication	Gene
Volume	835
Online published	13 Jun 2022
Publication status	Published - 15 Aug 2022

Link(s)

DOI	DOI https://doi.org/10.1016/j.gene.2022.146657 Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85132760407&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(98393cc3-84c7-44a8-9dc5-960e1576271c).html

Abstract

Bladder urothelial carcinoma (BLCA) is a complex disease with high morbidity and mortality. Changes in alternative splicing (AS) and splicing factor (SF) can affect gene expression, thus playing an essential role in tumorigenesis. This study downloaded 412 patients' clinical information and 433 samples of transcriptome profiling data from TCGA. And we collected 48 AS signatures from SpliceSeq. LASSO and Cox analyses were used for identifying survival-related AS events in BLCA. Finally, 1,645 OS-related AS events in 1,129 genes were validated by Kaplan-Meier (KM) survival analysis, ROC analysis, risk curve analysis, and independent prognostic analysis. Finally, our survey provides an AS-SF regulation network consisting of five SFs and 46 AS events. In the end, we profiled genes that AS occurred in pan-cancer and five SFs' expression in tumor and normal samples in BLCA. We selected CLIP-seq data for validation the interaction regulated by RBP. Our study paves the way for potential therapeutic targets of BLCA.

Research Area(s)

Alternative splicing (AS), Splicing factor (SF), Bladder urothelial carcinoma (BLCA), TCGA, Prognostic analysis

SDG 3 - Good Health and Well-being

Citation Format(s)

[ RIS ] [ BibTeX ]

The comprehensive and systematic identification of BLCA-specific SF-regulated, survival-related AS events. / Liu, Zhe; Liu, Xudong; Liu, Fang et al.
In: Gene, Vol. 835, 146657, 15.08.2022.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Liu, Z, Liu, X, Liu, F, Zhao, H, Zhang, Y, Wang, Y, Ma, Y, Wang, F , Zhang, W , Petinrin, OO , Yao, Z , Liang, J , He, Q, Feng, D, Wang, L & Wong, K-C 2022, 'The comprehensive and systematic identification of BLCA-specific SF-regulated, survival-related AS events', Gene, vol. 835, 146657. https://doi.org/10.1016/j.gene.2022.146657

Liu, Z., Liu, X., Liu, F., Zhao, H., Zhang, Y., Wang, Y., Ma, Y., Wang, F., Zhang, W., Petinrin, O. O., Yao, Z., Liang, J., He, Q., Feng, D., Wang, L., & Wong, K.-C. (2022). The comprehensive and systematic identification of BLCA-specific SF-regulated, survival-related AS events. Gene, 835, Article 146657. https://doi.org/10.1016/j.gene.2022.146657

Liu Z, Liu X, Liu F, Zhao H, Zhang Y, Wang Y et al. The comprehensive and systematic identification of BLCA-specific SF-regulated, survival-related AS events. Gene. 2022 Aug 15;835:146657. Epub 2022 Jun 13. doi: 10.1016/j.gene.2022.146657

Liu, Zhe ; Liu, Xudong ; Liu, Fang et al. / The comprehensive and systematic identification of BLCA-specific SF-regulated, survival-related AS events. In: Gene. 2022 ; Vol. 835.