TY - GEN
T1 - The applications of integrated microfluidic chips on automatic diagnosis systems
AU - Wang, Chih-Hao
AU - Lee, Gwo-Bin
N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].
PY - 2005
Y1 - 2005
N2 - The present study reports an integrated microfluidic chip for automatic diagnosis applications. A new "S-shape" micromachine-based pneumatic pump using the concept of the time delay of the compressed air flow is adopted to transport a minute amount of samples/reagents and automate the diagnosis process. While compared to traditional pneumatic micropumps, the new S-shape micropumps provide a higher pumping rate, and more importantly, simplify the control system. The new micromachine-based pneumatic valves and pumps formed by PDMS membranes are designed and fabricated using MEMS (Micro-electro-mechanical- systems) technology and are integrated to form an automatic bio-sensing chip for fast diagnosis of the infectious diseases. Experimental data show that the driving frequency, the quantity of the intersections, and the length of the S-shape microchannel could affect the pumping rate. The bio-sensing chips integrated with the micro-pneumatic valves and the S-shape pumps could successfully execute ELISA (Enzyme-linked immunosorbent assay)-based tests using less amounts of samples and reagents within a shorter time period. The development of the automatic bio-sensing chips could provide a useful tool for fast disease detection and be crucial for a micro-total-analysis system. ©2005 IEEE.
AB - The present study reports an integrated microfluidic chip for automatic diagnosis applications. A new "S-shape" micromachine-based pneumatic pump using the concept of the time delay of the compressed air flow is adopted to transport a minute amount of samples/reagents and automate the diagnosis process. While compared to traditional pneumatic micropumps, the new S-shape micropumps provide a higher pumping rate, and more importantly, simplify the control system. The new micromachine-based pneumatic valves and pumps formed by PDMS membranes are designed and fabricated using MEMS (Micro-electro-mechanical- systems) technology and are integrated to form an automatic bio-sensing chip for fast diagnosis of the infectious diseases. Experimental data show that the driving frequency, the quantity of the intersections, and the length of the S-shape microchannel could affect the pumping rate. The bio-sensing chips integrated with the micro-pneumatic valves and the S-shape pumps could successfully execute ELISA (Enzyme-linked immunosorbent assay)-based tests using less amounts of samples and reagents within a shorter time period. The development of the automatic bio-sensing chips could provide a useful tool for fast disease detection and be crucial for a micro-total-analysis system. ©2005 IEEE.
KW - Diagnosis
KW - ELISA
KW - MEMS
KW - Pneumatic pump
UR - http://www.scopus.com/inward/record.url?scp=33947622070&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-33947622070&origin=recordpage
U2 - 10.1109/robio.2005.246272
DO - 10.1109/robio.2005.246272
M3 - RGC 32 - Refereed conference paper (with host publication)
SN - 0780393155
SN - 9780780393158
VL - 2005
T3 - 2005 IEEE International Conference on Robotics and Biomimetics, ROBIO
SP - 251
EP - 256
BT - 2005 IEEE International Conference on Robotics and Biomimetics, ROBIO
T2 - 2005 IEEE International Conference on Robotics and Biomimetics (ROBIO 2005)
Y2 - 5 July 2005 through 9 July 2005
ER -