The anterior cingulate cortex directly enhances auditory cortical responses in air-puffing-facilitated flight behavior

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

9 Scopus Citations
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Detail(s)

Original languageEnglish
Article number110506
Journal / PublicationCell Reports
Volume38
Issue number10
Online published8 Mar 2022
Publication statusPublished - 8 Mar 2022

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Abstract

For survival, animals encode prominent events in complex environments, which modulates their defense behavior. Here, we design a paradigm that assesses how a mild aversive cue (i.e., mild air puff) interacts with sound-evoked flight behavior in mice. We find that air puffing facilitates sound-evoked flight behavior by enhancing the auditory responses of auditory cortical neurons. We then find that the anterior part of the anterior cingulate cortex (ACC) encodes the valence of air puffing and modulates the auditory cortex through anatomical examination, physiological recordings, and optogenetic/chemogenetic manipulations. Activating ACC projections to the auditory cortex simulates the facilitating effect of air puffing, whereas inhibiting the ACC or its projections to the auditory cortex neutralizes this facilitating effect. These findings show that the ACC regulates sound-evoked flight behavior by potentiating neuronal responses in the auditory cortex.

Research Area(s)

  • TOP-DOWN MODULATION, PREFRONTAL CORTEX, PREPULSE INHIBITION, LONG-RANGE, CIRCUIT, PATHWAY, CHOLECYSTOKININ, MECHANISMS, PLASTICITY, STARTLE

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