Abstract
Background: Engineered organogenesis is one of the most challenging areas on the cutting edge of regenerative medicine. Growth factors can affect cell proliferation, migration and differentiation profoundly, and thus play a critical role in tissue regeneration. TGF-βs produce a wide range of effects in different cells and tissues. TGF-β3 is relatively recently discovered and studied. Objective: To provide a broader understanding of the current state of TGF-β3 in engineered osteogenesis, chondrogenesis, palate development, scar-free wound healing, odontogenesis and neurogenesis. Methods: This review summarizes studies that explore or apply TGF-β3 for organogenesis with engineering methodology and a regenerative medical perspective. Results/conclusion: TGF-β3 has proven to be a competent growth factor in engineered organogenesis in vitro. In recent years, using TGF-β3, more and more in vivo studies have yielded significant therapeutic achievements in animal models, which bear much promise for future medical application. © 2008 Informa UK Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 1485-1493 |
| Journal | Expert Opinion on Biological Therapy |
| Volume | 8 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2008 |
| Externally published | Yes |
Bibliographical note
Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].Research Keywords
- Organogenesis
- Tissue engineering
- Transforming growth factor-beta 3
Policy Impact
- Cited in Policy Documents
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