Terretonin biosynthesis requires methylation as essential step for cyclization

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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Author(s)

  • Takayoshi Awakawa
  • Takayuki Itoh
  • Toshiyuki Wakimoto
  • Tetsuo Kushiro
  • Isao Fujii
  • Yutaka Ebizuka
  • Ikuro Abe

Detail(s)

Original languageEnglish
Pages (from-to)1738-1741
Journal / PublicationChemBioChem
Volume13
Issue number12
Online published10 Jul 2012
Publication statusPublished - 13 Aug 2012
Externally publishedYes

Link(s)

DOI

DOI
Check@CityULib
Link to Scopus https://www.scopus.com/record/display.uri?eid=2-s2.0-84864746120&origin=recordpage
Permanent Link https://scholars.cityu.edu.hk/en/publications/publication(ee760131-dda3-44cd-8bfd-3e2612a90d20).html

Abstract

Unexpected methylation: Terretonin is a fungal meroterpenoid derived from 3,5‐dimethylorsellinic acid (DMOA). Trt1 is a terpene cyclase involved in terretonin biosynthesis and only accepts the methylated compound as a substrate to produce the cyclized product. Methylation is a common requirement for the cyclization steps in DMOA‐derived meroterpenoid biosynthesis.

Research Area(s)

  • Biosynthesis, Enzymes, Meroterpenoids, Terpene cyclases, Terretonin

Fingerprint

Publication fingerprints text

100
cyclization INIS
100
methylation INIS
100
biosynthesis INIS
100
Methylation Keyphrases
100
Cyclization Keyphrases
100
Terretonin Keyphrases
66
Meroterpenoid Chemistry
33
substrates INIS
33
cyclases INIS
33
terpenes INIS
Full Fingerprint ›

Citation Format(s)

[ RIS ] [ BibTeX ]
Terretonin biosynthesis requires methylation as essential step for cyclization. / Matsuda, Yudai; Awakawa, Takayoshi; Itoh, Takayuki et al.
In: ChemBioChem, Vol. 13, No. 12, 13.08.2012, p. 1738-1741.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review