TY - JOUR
T1 - Ternary Chalcogenide Nanosheets with Ultrahigh Photothermal Conversion Efficiency for Photoacoustic Theranostics
AU - Zhu, Houjuan
AU - Lai, Zhuangchai
AU - Fang, Yuan
AU - Zhen, Xu
AU - Tan, Chaoliang
AU - Qi, Xiaoying
AU - Ding, Dan
AU - Chen, Peng
AU - Zhang, Hua
AU - Pu, Kanyi
PY - 2017/4/25
Y1 - 2017/4/25
N2 - 2D materials (TDMs) have been explored for photonic theranostics. To achieve deep-tissue penetration, near-infrared (NIR) light is essential for photoacoustic (PA) theranostics. However, because the absorption profiles of existing TDMs are generally featureless with no obvious NIR absorption peaks, their PA signals and therapeutic efficacies are limited. This paper herein reports the synthesis and application of ternary chalcogenide nanosheets (Ta2NiS5-P) for PA theranostics. In contrast to the current TDMs for such application, Ta2NiS5-P has a ternary instead of binary composition. This difference brings in the strong and featured NIR for Ta2NiS5-P. To the best of the knowledge, this is the first example using ternary chalcogenide nanosheets for such application; moreover, the photothermal conversion efficiency of Ta2 NiS5-P is the highest (35%) among all the reported TDMs based on the same calculation method. These advantages allow Ta2NiS5-P to passively target, effectively delineate, and completely eradicate the tumor of living mice after systemic administration.
AB - 2D materials (TDMs) have been explored for photonic theranostics. To achieve deep-tissue penetration, near-infrared (NIR) light is essential for photoacoustic (PA) theranostics. However, because the absorption profiles of existing TDMs are generally featureless with no obvious NIR absorption peaks, their PA signals and therapeutic efficacies are limited. This paper herein reports the synthesis and application of ternary chalcogenide nanosheets (Ta2NiS5-P) for PA theranostics. In contrast to the current TDMs for such application, Ta2NiS5-P has a ternary instead of binary composition. This difference brings in the strong and featured NIR for Ta2NiS5-P. To the best of the knowledge, this is the first example using ternary chalcogenide nanosheets for such application; moreover, the photothermal conversion efficiency of Ta2 NiS5-P is the highest (35%) among all the reported TDMs based on the same calculation method. These advantages allow Ta2NiS5-P to passively target, effectively delineate, and completely eradicate the tumor of living mice after systemic administration.
KW - 2D materials
KW - photoacoustic imaging
KW - photothermal therapy
KW - theranostics
UR - http://www.scopus.com/inward/record.url?scp=85013218930&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85013218930&origin=recordpage
U2 - 10.1002/smll.201604139
DO - 10.1002/smll.201604139
M3 - RGC 21 - Publication in refereed journal
C2 - 28186370
SN - 1613-6810
VL - 13
JO - Small
JF - Small
IS - 16
M1 - 1604139
ER -