Taurine inhibits rat substantia nigra pars reticulata neurons by activation of GABA- and glycine-linked chloride conductance

Gui-Lan Ye; Andrew C. O. Tse; Wing-Ho Yung

doi:10.1016/S0006-8993(96)01427-8

Taurine inhibits rat substantia nigra pars reticulata neurons by activation of GABA- and glycine-linked chloride conductance

Gui-Lan Ye, Andrew C. O. Tse, Wing-Ho Yung

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

51 Citations (Scopus)

Abstract

Whole-cell recordings from rat midbrain slices showed that bath application of taurine (30 μM-10 mM) reversibly hyperpolarized and inhibited the firing of substantia nigra pars reticulata neurons. These effects were mediated by an increase in membrane chloride conductance. Taurine cross-desensitized with GABA and glycine. Strychnine competitively antagonized the actions of glycine and taurine but not that of GABA. On the other hand, the responses to taurine and glycine were not sensitive to bicuculline. These findings suggest that taurine inhibits SNR neurons by opening GABA and glycine-linked chloride channels.

Original language	English
Pages (from-to)	175-179
Journal	Brain Research
Volume	749
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(96)01427-8
Publication status	Published - 21 Feb 1997
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Research Keywords

γ-Aminobutyric acid (GABA)
Bicuculline
Chloride channel
Glycine
Strychnine
Substantia nigra
Taurine

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@article{4135400641ea425b9f1ac2ad53612153,

title = "Taurine inhibits rat substantia nigra pars reticulata neurons by activation of GABA- and glycine-linked chloride conductance",

abstract = "Whole-cell recordings from rat midbrain slices showed that bath application of taurine (30 μM-10 mM) reversibly hyperpolarized and inhibited the firing of substantia nigra pars reticulata neurons. These effects were mediated by an increase in membrane chloride conductance. Taurine cross-desensitized with GABA and glycine. Strychnine competitively antagonized the actions of glycine and taurine but not that of GABA. On the other hand, the responses to taurine and glycine were not sensitive to bicuculline. These findings suggest that taurine inhibits SNR neurons by opening GABA and glycine-linked chloride channels.",

keywords = "γ-Aminobutyric acid (GABA), Bicuculline, Chloride channel, Glycine, Strychnine, Substantia nigra, Taurine",

author = "Gui-Lan Ye and Tse, {Andrew C. O.} and Wing-Ho Yung",

note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].",

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T1 - Taurine inhibits rat substantia nigra pars reticulata neurons by activation of GABA- and glycine-linked chloride conductance

AU - Ye, Gui-Lan

AU - Tse, Andrew C. O.

AU - Yung, Wing-Ho

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 1997/2/21

Y1 - 1997/2/21

N2 - Whole-cell recordings from rat midbrain slices showed that bath application of taurine (30 μM-10 mM) reversibly hyperpolarized and inhibited the firing of substantia nigra pars reticulata neurons. These effects were mediated by an increase in membrane chloride conductance. Taurine cross-desensitized with GABA and glycine. Strychnine competitively antagonized the actions of glycine and taurine but not that of GABA. On the other hand, the responses to taurine and glycine were not sensitive to bicuculline. These findings suggest that taurine inhibits SNR neurons by opening GABA and glycine-linked chloride channels.

AB - Whole-cell recordings from rat midbrain slices showed that bath application of taurine (30 μM-10 mM) reversibly hyperpolarized and inhibited the firing of substantia nigra pars reticulata neurons. These effects were mediated by an increase in membrane chloride conductance. Taurine cross-desensitized with GABA and glycine. Strychnine competitively antagonized the actions of glycine and taurine but not that of GABA. On the other hand, the responses to taurine and glycine were not sensitive to bicuculline. These findings suggest that taurine inhibits SNR neurons by opening GABA and glycine-linked chloride channels.

KW - γ-Aminobutyric acid (GABA)

KW - Bicuculline

KW - Chloride channel

KW - Glycine

KW - Strychnine

KW - Substantia nigra

KW - Taurine

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U2 - 10.1016/S0006-8993(96)01427-8

DO - 10.1016/S0006-8993(96)01427-8

M3 - RGC 21 - Publication in refereed journal

C2 - 9070647

SN - 0006-8993

VL - 749

SP - 175

EP - 179

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Taurine inhibits rat substantia nigra pars reticulata neurons by activation of GABA- and glycine-linked chloride conductance

Abstract

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Research Keywords

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