Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease

Hendrik Wesseling; Waltraud Mair; Mukesh Kumar; Christoph N. Schlaffner; Shaojun Tang; Pieter Beerepoot; Benoit Fatou; Amanda J. Guise; Long Cheng; Shuko Takeda; Jan Muntel; Melissa S. Rotunno; Simon Dujardin; Peter Davies; Kenneth S. Kosik; Bruce L. Miller; Sabina Berretta; John C. Hedreen; Lea T. Grinberg; William W. Seeley; Bradley T. Hyman; Hanno Steen; Judith A. Steen

doi:10.1016/j.cell.2020.10.029

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease

Hendrik Wesseling
, Waltraud Mair
, Mukesh Kumar
, Christoph N. Schlaffner
, Shaojun Tang
, Pieter Beerepoot
, Benoit Fatou
, Amanda J. Guise
, Long Cheng
, Shuko Takeda
, Jan Muntel
, Melissa S. Rotunno
, Simon Dujardin
, Peter Davies
, Kenneth S. Kosik
, Bruce L. Miller
, Sabina Berretta
, John C. Hedreen
, Lea T. Grinberg
, William W. Seeley

Bradley T. Hyman, Hanno Steen, Judith A. Steen^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

555 Citations (Scopus)

Abstract

A high-resolution quantitative proteomics map of post-translational modifications on multiple isoforms of Tau shows heterogeneity across Alzheimer's disease patients, reflective of disease progression, and identifies critical targets at each stage of disease.

Original language	English
Article number	e13
Pages (from-to)	1699-1713
Journal	Cell
Volume	183
Issue number	6
Online published	13 Nov 2020
DOIs	https://doi.org/10.1016/j.cell.2020.10.029
Publication status	Published - 10 Dec 2020
Externally published	Yes

Research Keywords

absolute quantification
disease progression
FLEXITau
multiple reaction monitoring (MRM)
post-translational modifications
prion-like molecules
protein aggregation
proteomics
proteopathy
quantitative mass spectrometry

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Wesseling, H., Mair, W., Kumar, M., Schlaffner, C. N., Tang, S., Beerepoot, P., Fatou, B., Guise, A. J., Cheng, L., Takeda, S., Muntel, J., Rotunno, M. S., Dujardin, S., Davies, P., Kosik, K. S., Miller, B. L., Berretta, S., Hedreen, J. C., Grinberg, L. T., ... Steen, J. A. (2020). Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease. Cell, 183(6), 1699-1713. Article e13. https://doi.org/10.1016/j.cell.2020.10.029

@article{4146fcf2ea434cff885163d93cf74139,

title = "Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease",

abstract = "A high-resolution quantitative proteomics map of post-translational modifications on multiple isoforms of Tau shows heterogeneity across Alzheimer's disease patients, reflective of disease progression, and identifies critical targets at each stage of disease.",

keywords = "absolute quantification, disease progression, FLEXITau, multiple reaction monitoring (MRM), post-translational modifications, prion-like molecules, protein aggregation, proteomics, proteopathy, quantitative mass spectrometry",

author = "Hendrik Wesseling and Waltraud Mair and Mukesh Kumar and Schlaffner, \{Christoph N.\} and Shaojun Tang and Pieter Beerepoot and Benoit Fatou and Guise, \{Amanda J.\} and Long Cheng and Shuko Takeda and Jan Muntel and Rotunno, \{Melissa S.\} and Simon Dujardin and Peter Davies and Kosik, \{Kenneth S.\} and Miller, \{Bruce L.\} and Sabina Berretta and Hedreen, \{John C.\} and Grinberg, \{Lea T.\} and Seeley, \{William W.\} and Hyman, \{Bradley T.\} and Hanno Steen and Steen, \{Judith A.\}",

year = "2020",

month = dec,

day = "10",

doi = "10.1016/j.cell.2020.10.029",

language = "English",

volume = "183",

pages = "1699--1713",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "6",

}

Wesseling, H, Mair, W, Kumar, M, Schlaffner, CN, Tang, S, Beerepoot, P, Fatou, B, Guise, AJ, Cheng, L, Takeda, S, Muntel, J, Rotunno, MS, Dujardin, S, Davies, P, Kosik, KS, Miller, BL, Berretta, S, Hedreen, JC, Grinberg, LT, Seeley, WW, Hyman, BT, Steen, H & Steen, JA 2020, 'Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease', Cell, vol. 183, no. 6, e13, pp. 1699-1713. https://doi.org/10.1016/j.cell.2020.10.029

TY - JOUR

T1 - Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease

AU - Wesseling, Hendrik

AU - Mair, Waltraud

AU - Kumar, Mukesh

AU - Schlaffner, Christoph N.

AU - Tang, Shaojun

AU - Beerepoot, Pieter

AU - Fatou, Benoit

AU - Guise, Amanda J.

AU - Cheng, Long

AU - Takeda, Shuko

AU - Muntel, Jan

AU - Rotunno, Melissa S.

AU - Dujardin, Simon

AU - Davies, Peter

AU - Kosik, Kenneth S.

AU - Miller, Bruce L.

AU - Berretta, Sabina

AU - Hedreen, John C.

AU - Grinberg, Lea T.

AU - Seeley, William W.

AU - Hyman, Bradley T.

AU - Steen, Hanno

AU - Steen, Judith A.

PY - 2020/12/10

Y1 - 2020/12/10

N2 - A high-resolution quantitative proteomics map of post-translational modifications on multiple isoforms of Tau shows heterogeneity across Alzheimer's disease patients, reflective of disease progression, and identifies critical targets at each stage of disease.

AB - A high-resolution quantitative proteomics map of post-translational modifications on multiple isoforms of Tau shows heterogeneity across Alzheimer's disease patients, reflective of disease progression, and identifies critical targets at each stage of disease.

KW - absolute quantification

KW - disease progression

KW - FLEXITau

KW - multiple reaction monitoring (MRM)

KW - post-translational modifications

KW - prion-like molecules

KW - protein aggregation

KW - proteomics

KW - proteopathy

KW - quantitative mass spectrometry

UR - https://www.scopus.com/pages/publications/85097054041

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85097054041&origin=recordpage

U2 - 10.1016/j.cell.2020.10.029

DO - 10.1016/j.cell.2020.10.029

M3 - RGC 21 - Publication in refereed journal

C2 - 33188775

SN - 0092-8674

VL - 183

SP - 1699

EP - 1713

JO - Cell

JF - Cell

IS - 6

M1 - e13

ER -

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease

Abstract

Research Keywords

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