Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
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Detail(s)
Original language | English |
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Pages (from-to) | 1181-1197 |
Journal / Publication | Theranostics |
Volume | 10 |
Issue number | 3 |
Online published | 1 Jan 2020 |
Publication status | Published - Feb 2020 |
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DOI | DOI |
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Attachment(s) | Documents
Publisher's Copyright Statement
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Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85077607338&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(e2054204-aaee-4a67-97db-e16842d02f35).html |
Abstract
Cancer stem cells (CSCs) have been implicated in cancer recurrence and therapy resistance. Therefore,a CSC-targeted therapy that disrupts the maintenance and survival of CSCs may offer an effectiveapproach in killing tumor cells in primary tumors and preventing the metastasis caused by CSCs.Nanoparticles (NPs)-based thermotherapy and/or chemotherapy are promising therapeutic methods forcancer treatment.
Methods: A silica-based multifunctional NP system was present, which encapsulated achemotherapeutic agent and magnetic cores and coated with a specific antibody against the lung CSCs.The efficacy of this novel therapeutic strategy was systematically studied both in vitro and in vivo bysimultaneous activating the combined thermotherapy and chemotherapy via CSC-targeted NPs.
Results: These NPs were systematically administered and activated for targeted chemotherapy andthermotherapy by using an externally applied alternating magnetic field (AMF). The antibody-modifiedNPs targeted to lung CSCs with enhanced cellular uptake in vitro and extended accumulation in tumor invivo. Up to 98% of lung CSCs was killed in vitro with 30-min application of AMF, due to the combinedeffects of hyperthermia and chemotherapeutic drug treatment. In in vivo models, this combined therapysignificantly suppressed tumor growth and metastasis in lung CSC xenograft-bearing mice, with minimalside effects and adverse effects.
Conclusion: With good biocompatibility and targeting capability, the nanodrug delivery system mayoffer a promising clinical platform for the combined thermotherapy and chemotherapy. This workdemonstrated the feasibility of developing multifunctional nanomedicine targeting CSCs for effectivecancer treatment.
Methods: A silica-based multifunctional NP system was present, which encapsulated achemotherapeutic agent and magnetic cores and coated with a specific antibody against the lung CSCs.The efficacy of this novel therapeutic strategy was systematically studied both in vitro and in vivo bysimultaneous activating the combined thermotherapy and chemotherapy via CSC-targeted NPs.
Results: These NPs were systematically administered and activated for targeted chemotherapy andthermotherapy by using an externally applied alternating magnetic field (AMF). The antibody-modifiedNPs targeted to lung CSCs with enhanced cellular uptake in vitro and extended accumulation in tumor invivo. Up to 98% of lung CSCs was killed in vitro with 30-min application of AMF, due to the combinedeffects of hyperthermia and chemotherapeutic drug treatment. In in vivo models, this combined therapysignificantly suppressed tumor growth and metastasis in lung CSC xenograft-bearing mice, with minimalside effects and adverse effects.
Conclusion: With good biocompatibility and targeting capability, the nanodrug delivery system mayoffer a promising clinical platform for the combined thermotherapy and chemotherapy. This workdemonstrated the feasibility of developing multifunctional nanomedicine targeting CSCs for effectivecancer treatment.
Research Area(s)
- Lung cancer stem cell, Multifunctional nanoparticle, Alternating magnetic field, Thermotherapy and chemotherapy, TUMOR-CELLS, RESISTANCE, DELIVERY, AXIS, DIFFERENTIATION, ACTIVATION, PATHWAYS, HEDGEHOG
Citation Format(s)
Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy. / Liu, Dandan; Hong, Yingcai; Li, Yaping; Hu, Chong; Yip, Tak-Chun; Yu, Wai-Kin; Zhu, Yu; Fong, Chi-Chun; Wang, Weimao; Au, Siu-Kie; Wang, Shubin; Yang, Mengsu.
In: Theranostics, Vol. 10, No. 3, 02.2020, p. 1181-1197.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
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