Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

13 Scopus Citations
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Author(s)

  • Dandan Liu
  • Yingcai Hong
  • Yaping Li
  • Chong Hu
  • Tak-Chun Yip
  • Yu Zhu
  • Chi-Chun Fong
  • Weimao Wang
  • Siu-Kie Au
  • Shubin Wang

Detail(s)

Original languageEnglish
Pages (from-to)1181-1197
Journal / PublicationTheranostics
Volume10
Issue number3
Online published1 Jan 2020
Publication statusPublished - Feb 2020

Link(s)

Abstract

Cancer stem cells (CSCs) have been implicated in cancer recurrence and therapy resistance. Therefore,a CSC-targeted therapy that disrupts the maintenance and survival of CSCs may offer an effectiveapproach in killing tumor cells in primary tumors and preventing the metastasis caused by CSCs.Nanoparticles (NPs)-based thermotherapy and/or chemotherapy are promising therapeutic methods forcancer treatment. 
Methods: A silica-based multifunctional NP system was present, which encapsulated achemotherapeutic agent and magnetic cores and coated with a specific antibody against the lung CSCs.The efficacy of this novel therapeutic strategy was systematically studied both in vitro and in vivo bysimultaneous activating the combined thermotherapy and chemotherapy via CSC-targeted NPs. 
Results: These NPs were systematically administered and activated for targeted chemotherapy andthermotherapy by using an externally applied alternating magnetic field (AMF). The antibody-modifiedNPs targeted to lung CSCs with enhanced cellular uptake in vitro and extended accumulation in tumor invivo. Up to 98% of lung CSCs was killed in vitro with 30-min application of AMF, due to the combinedeffects of hyperthermia and chemotherapeutic drug treatment. In in vivo models, this combined therapysignificantly suppressed tumor growth and metastasis in lung CSC xenograft-bearing mice, with minimalside effects and adverse effects. 
Conclusion: With good biocompatibility and targeting capability, the nanodrug delivery system mayoffer a promising clinical platform for the combined thermotherapy and chemotherapy. This workdemonstrated the feasibility of developing multifunctional nanomedicine targeting CSCs for effectivecancer treatment.

Research Area(s)

  • Lung cancer stem cell, Multifunctional nanoparticle, Alternating magnetic field, Thermotherapy and chemotherapy, TUMOR-CELLS, RESISTANCE, DELIVERY, AXIS, DIFFERENTIATION, ACTIVATION, PATHWAYS, HEDGEHOG

Citation Format(s)

Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy. / Liu, Dandan; Hong, Yingcai; Li, Yaping; Hu, Chong; Yip, Tak-Chun; Yu, Wai-Kin; Zhu, Yu; Fong, Chi-Chun; Wang, Weimao; Au, Siu-Kie; Wang, Shubin; Yang, Mengsu.

In: Theranostics, Vol. 10, No. 3, 02.2020, p. 1181-1197.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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