Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

View graph of relations

Author(s)

  • Dandan Liu
  • Yingcai Hong
  • Yaping Li
  • Chong Hu
  • Tak-Chun Yip
  • Yu Zhu
  • Chi-Chun Fong
  • Weimao Wang
  • Siu-Kie Au
  • Shubin Wang
  • Mengsu Yang

Detail(s)

Original languageEnglish
Pages (from-to)1181-1196
Journal / PublicationTheranostics
Volume10
Issue number3
Online published1 Jan 2020
Publication statusPublished - Feb 2020

Abstract

Cancer stem cells (CSCs) have been implicated in cancer recurrence and therapy resistance. Therefore, a CSC-targeted therapy that disrupts the maintenance and survival of CSCs may offer an effective approach in killing tumor cells in primary tumors and preventing the metastasis caused by CSCs. Nanoparticles (NPs)-based thermotherapy and/or chemotherapy are promising therapeutic methods forcancer treatment.

Methods: A silica-based multifunctional NP system was present, which encapsulated a chemotherapeutic agent and magnetic cores and coated with a specific antibody against the lung CSCs. The efficacy of this novel therapeutic strategy was systematically studied both in vitro and in vivo by simultaneous activating the combined thermotherapy and chemotherapyvia CSC-targeted NPs.

Results: These NPs were systematically administered and activated for targeted chemotherapy and thermotherapy by using an externally applied alternating magnetic field (AMF). The antibody-modified NPs targeted to lung CSCs with enhanced cellular uptake in vitro and extended accumulation in tumor in vivo. Up to 98% of lung CSCs was killed in vitrowith 30-min application of AMF, due to the combined effects of hyperthermia and chemotherapeutic drug treatment. In in vivo models, this combined therapy significantly suppressed tumor growth and metastasis in lung CSC xenograft-bearing mice, with minimal side effects and adverse effects.

Conclusion: With good biocompatibility and targeting capability, the nanodrug delivery system may offer a promising clinical platform for the combined thermotherapy and chemotherapy. This work demonstrated the feasibility of developing multifunctional nanomedicine targeting CSCs for effective cancer treatment.

Research Area(s)

  • Lung cancer stem cell, Multifunctional nanoparticle, Alternating magnetic field, Thermotherapy and chemotherapy, TUMOR-CELLS, RESISTANCE, DELIVERY, AXIS, DIFFERENTIATION, ACTIVATION, PATHWAYS, HEDGEHOG

Citation Format(s)

Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy. / Liu, Dandan; Hong, Yingcai; Li, Yaping; Hu, Chong; Yip, Tak-Chun; Yu, Wai-Kin; Zhu, Yu; Fong, Chi-Chun; Wang, Weimao; Au, Siu-Kie; Wang, Shubin; Yang, Mengsu.

In: Theranostics, Vol. 10, No. 3, 02.2020, p. 1181-1196.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal