Targeted Delivery of Anesthetic Agents to Bone Tissues using Conductive Microneedles Enhanced Iontophoresis for Painless Dental Anesthesia

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Razina Z. Seeni
  • Mengjia Zheng
  • Daniel Chin Shiuan Lio
  • Christian Wiraja
  • Mohammad Firdaus Bin Mohd Yusoff
  • William Teck Yeow Koh
  • Yuchun Liu
  • Bee Tin Goh

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number2105686
Journal / PublicationAdvanced Functional Materials
Online published21 Aug 2021
Publication statusOnline published - 21 Aug 2021

Abstract

Pain management during dental procedures is a cornerstone for successful daily practice. In current practice, the traditional needle and syringe injection is used to administer local anesthesia. However, the appearance of long needles and the pain associated with it often leads to dental anxiety deterring timely interventions. Microneedles (MNs) have emerged as a minimally invasive alternative to hypodermic needles and shown to be effective in transdermal drug delivery applications. In this article, the potential use of MNs for local anesthesia delivery in dentistry is explored. The development of a novel conductive MN array that can be used in combination with iontophoresis technique to achieve drug penetration through the oral mucosa and the underlying bone tissue is presented. The conductive MN array plays a dual-role, creating micro-conduits and lowering the resistance of the oral mucosa. The reduced tissue resistance further enhances the application of a low-voltage current that is able to direct and accelerate the drug molecules to target the sensory nerves supplying teeth. The successful delivery of lidocaine using this new strategy in a clinically relevant rabbit incisor model is shown to be as effective as the current gold standard.

Research Area(s)

  • bones, dentistry, drug delivery, iontophoresis, microneedles

Citation Format(s)

Targeted Delivery of Anesthetic Agents to Bone Tissues using Conductive Microneedles Enhanced Iontophoresis for Painless Dental Anesthesia. / Seeni, Razina Z.; Zheng, Mengjia; Lio, Daniel Chin Shiuan; Wiraja, Christian; Mohd Yusoff, Mohammad Firdaus Bin; Koh, William Teck Yeow; Liu, Yuchun; Goh, Bee Tin; Xu, Chenjie.

In: Advanced Functional Materials, 21.08.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review