Targeted brain tumor imaging by using discrete biopolymer-coated nanodiamonds across the blood-brain barrier

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Pages (from-to)3184-3193
Journal / PublicationNanoscale
Volume13
Issue number5
Online published2 Jan 2021
Publication statusPublished - 7 Feb 2021

Abstract

Short circulation lifetime, poor blood brain barrier (BBB) permeability and low targeting specificity limit nano vehicles from crossing vascular barrier and reaching tumor site. Consequently, the precise diagnosis of malignant brain tumors remains a great challenge. This study demonstrates the imaging of photostable biopolymer-coated nanodiamonds (NDs) with tumor targeting property inside the brain. NDs are labeled with PEGylated denatured bovine serum albumin (BSA) and tumor vasculature targeting tripeptides RGD. The modified NDs maintain high colloidal stability in different buffer systems. Moreover, it is found that discrete dcBSA-PEG-NDs cross the in vitro BBB model more effectively than aggregated NDs. Importantly, compared with the non-targeting NDs, RGD-dcBSA-PEG-NDs can selectively target tumor site in U-87 MG bearing mice after systemic injection. Overall, this discrete ND system enables efficacious brain tumor visualization with minimal toxicity to other major organs, and is worthy of further investigation into the applications as a unique platform for noninvasive theragnostic and/or thermometry at different stages of human diseases in the brain.

Citation Format(s)

Targeted brain tumor imaging by using discrete biopolymer-coated nanodiamonds across the blood-brain barrier. / Leung, Hoi Man; Lau, Cia Hin; Ho, Jonathan Weng-Thim; Chan, Miu Shan; Chang, Tristan Juin Han; Law, Lok Hin; Wang, Fei; Tam, Dick Yan; Liu, Ling Sum; Chan, Kannie Wai Yan; Tin, Chung; Lo, Pik Kwan.

In: Nanoscale, Vol. 13, No. 5, 07.02.2021, p. 3184-3193.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review