Synthesis of Zinc Oxide Eudragit FS30D Nanohybrids : Structure, Characterization, and Their Application as an Intestinal Drug Delivery System

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Fan Luo
  • Mingjie Wang
  • Liting Huang
  • Ziqian Wu
  • Ayesha Zafar
  • Yunbo Tian
  • Murtaza Hasan
  • Xugang Shu

Detail(s)

Original languageEnglish
Pages (from-to)11799–11808
Journal / PublicationACS Omega
Volume5
Issue number20
Online published13 May 2020
Publication statusPublished - 26 May 2020

Link(s)

Abstract

The present study was designed to develop multifunctional zinc oxide-encapsulated Eudragit FS30D (ZnO/EFS) nanohybrid structures as a biodegradable drug delivery system and as a promising successful carrier for targeting sites. The solvent evaporation method was used to fabricate the ZnO/EFS nanohybrids and the size, shape, stability, and antioxidant activity were characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), thermogravimetric analysis (TGA), and an antioxidant (1,1-diphenyl-2-picrylhydrazyl (DPPH)). Zinc oxide-encapsulated Eudragit FS30D (ZnO/EFS) nanohybrid structures consisted of irregularly shaped, 297.65 nm-sized ZnO/EFS microcapsule, enduring thermal stability from 251.17 to 385.67 °C. Nano-ZnO was encapsulated in EFS through the formation of hydrogen bonds, and the average encapsulation efficiency for nano-ZnO was determined to be 96.12%. In vitro intestinal-targeted drug release assay provided 91.86% with free nano-ZnO, only 9.5% in acidified ZnO/EFS nanohybrid structure but the rate ZnO/EFS nanohybrids reached 93.11% in succus entericus resultantly modified nano-ZnO was proven proficient intestinal-specific delivery system. The stability of the ZnO/EFS nanohybrid structures was confirmed using ζ-potential and antioxidant activity analysis. Hence, the EFS nanoencapsulation strategy of ZnO provided a stable, nontoxic, and pharmacokinetically active intestine-specific system that can become the best choice for an effective oral feed additive in future.

Research Area(s)

Citation Format(s)

Synthesis of Zinc Oxide Eudragit FS30D Nanohybrids : Structure, Characterization, and Their Application as an Intestinal Drug Delivery System. / Luo, Fan; Wang, Mingjie; Huang, Liting; Wu, Ziqian; Wang, Wenxiong; Zafar, Ayesha; Tian, Yunbo; Hasan, Murtaza; Shu, Xugang.

In: ACS Omega, Vol. 5, No. 20, 26.05.2020, p. 11799–11808.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review