Synthesis of a new chiral ligand, 6,6'-dihydroxy-5, 5'-biquinoline (BIQOL) and its applications in the asymmetric addition of diethylzinc to aldehydes

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Yi-Xin Chen
  • Li-Wei Yang
  • Yue-Ming Li
  • Zhong-Yuan Zhou
  • Kim-Hung Lam
  • Albert S. C. Chan

Detail(s)

Original languageEnglish
Pages (from-to)510-513
Journal / PublicationChirality
Volume12
Issue number5-6
Publication statusPublished - 2000

Abstract

A new chiral ligand 6, 6'-dihydroxy-5, 5'-biquinoline (BIQOL, 2) was prepared via Cu2+ mediated coupling. The resolution was carried out by separating the corresponding ditrifluomethanesulfonate on chiral column. When applied to the enantioselective addition of diethylzinc to aromatic aldehydes, this ligand induced the reaction with enantioselectivity equivalent to that induced by BINOL. The effects of solvent and reaction temperature on enantioselectivity were also studied. (C) 2000 Wiley-Liss, Inc.

Research Area(s)

  • BINOL, BIQOL, Diethylzinc, Quinoline

Citation Format(s)

Synthesis of a new chiral ligand, 6,6'-dihydroxy-5, 5'-biquinoline (BIQOL) and its applications in the asymmetric addition of diethylzinc to aldehydes. / Chen, Yi-Xin; Yang, Li-Wei; Li, Yue-Ming et al.
In: Chirality, Vol. 12, No. 5-6, 2000, p. 510-513.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review