Synthesis of a new chiral ligand, 6,6'-dihydroxy-5, 5'-biquinoline (BIQOL) and its applications in the asymmetric addition of diethylzinc to aldehydes
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 510-513 |
| Journal / Publication | Chirality |
| Volume | 12 |
| Issue number | 5-6 |
| Publication status | Published - 2000 |
Link(s)
Abstract
A new chiral ligand 6, 6'-dihydroxy-5, 5'-biquinoline (BIQOL, 2) was prepared via Cu2+ mediated coupling. The resolution was carried out by separating the corresponding ditrifluomethanesulfonate on chiral column. When applied to the enantioselective addition of diethylzinc to aromatic aldehydes, this ligand induced the reaction with enantioselectivity equivalent to that induced by BINOL. The effects of solvent and reaction temperature on enantioselectivity were also studied. (C) 2000 Wiley-Liss, Inc.
Research Area(s)
- BINOL, BIQOL, Diethylzinc, Quinoline
Citation Format(s)
Synthesis of a new chiral ligand, 6,6'-dihydroxy-5, 5'-biquinoline (BIQOL) and its applications in the asymmetric addition of diethylzinc to aldehydes. / Chen, Yi-Xin; Yang, Li-Wei; Li, Yue-Ming et al.
In: Chirality, Vol. 12, No. 5-6, 2000, p. 510-513.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
