Synthesis, dispersion, and cytocompatibility of graphene oxide and reduced graphene oxide

Malgorzata Wojtoniszak; Xuecheng Chen; Ryszard J. Kalenczuk; Anna Wajda; Joanna Łapczuk; Mateusz Kurzewski; Marek Drozdzik; Pual K. Chu; Ewa Borowiak-Palen

doi:10.1016/j.colsurfb.2011.08.026

Synthesis, dispersion, and cytocompatibility of graphene oxide and reduced graphene oxide

Malgorzata Wojtoniszak, Xuecheng Chen, Ryszard J. Kalenczuk, Anna Wajda, Joanna Łapczuk, Mateusz Kurzewski, Marek Drozdzik, Pual K. Chu, Ewa Borowiak-Palen

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

412 Citations (Scopus)

Abstract

The synthesis, characterization, and toxicity of graphene oxide and reduced graphene oxide are reported. Prior to the cytocompatibility tests the stability of the suspensions in a wide range of concentrations (3.125-100 μg/mL) of three different dispersants is studied. Polyethylene glycol (PEG), polyethylene glycol-polypropylene glycol-polyethylene glycol (Pluronic P123), and sodium deoxycholate (DOC) are investigated as the dispersants. The toxicity depends on the type of dispersant and concentration of the nanomaterials in the suspensions. Detailed analysis suggests that graphene oxide functionalized with PEG in the concentration range between 3125 μg/mL and 25 μg/mL exhibits the best biocompatibility with mice fibroblast cells (line L929). © 2011 Elsevier B.V.

Original language	English
Pages (from-to)	79-85
Journal	Colloids and Surfaces B: Biointerfaces
Volume	89
Issue number	1
DOIs	https://doi.org/10.1016/j.colsurfb.2011.08.026
Publication status	Published - 1 Jan 2012

Research Keywords

Graphene
Graphene oxide
In vitro toxicology

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title = "Synthesis, dispersion, and cytocompatibility of graphene oxide and reduced graphene oxide",

abstract = "The synthesis, characterization, and toxicity of graphene oxide and reduced graphene oxide are reported. Prior to the cytocompatibility tests the stability of the suspensions in a wide range of concentrations (3.125-100 μg/mL) of three different dispersants is studied. Polyethylene glycol (PEG), polyethylene glycol-polypropylene glycol-polyethylene glycol (Pluronic P123), and sodium deoxycholate (DOC) are investigated as the dispersants. The toxicity depends on the type of dispersant and concentration of the nanomaterials in the suspensions. Detailed analysis suggests that graphene oxide functionalized with PEG in the concentration range between 3125 μg/mL and 25 μg/mL exhibits the best biocompatibility with mice fibroblast cells (line L929). {\textcopyright} 2011 Elsevier B.V.",

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AU - Wojtoniszak, Malgorzata

AU - Chen, Xuecheng

AU - Kalenczuk, Ryszard J.

AU - Wajda, Anna

AU - Łapczuk, Joanna

AU - Kurzewski, Mateusz

AU - Drozdzik, Marek

AU - Chu, Pual K.

AU - Borowiak-Palen, Ewa

PY - 2012/1/1

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N2 - The synthesis, characterization, and toxicity of graphene oxide and reduced graphene oxide are reported. Prior to the cytocompatibility tests the stability of the suspensions in a wide range of concentrations (3.125-100 μg/mL) of three different dispersants is studied. Polyethylene glycol (PEG), polyethylene glycol-polypropylene glycol-polyethylene glycol (Pluronic P123), and sodium deoxycholate (DOC) are investigated as the dispersants. The toxicity depends on the type of dispersant and concentration of the nanomaterials in the suspensions. Detailed analysis suggests that graphene oxide functionalized with PEG in the concentration range between 3125 μg/mL and 25 μg/mL exhibits the best biocompatibility with mice fibroblast cells (line L929). © 2011 Elsevier B.V.

AB - The synthesis, characterization, and toxicity of graphene oxide and reduced graphene oxide are reported. Prior to the cytocompatibility tests the stability of the suspensions in a wide range of concentrations (3.125-100 μg/mL) of three different dispersants is studied. Polyethylene glycol (PEG), polyethylene glycol-polypropylene glycol-polyethylene glycol (Pluronic P123), and sodium deoxycholate (DOC) are investigated as the dispersants. The toxicity depends on the type of dispersant and concentration of the nanomaterials in the suspensions. Detailed analysis suggests that graphene oxide functionalized with PEG in the concentration range between 3125 μg/mL and 25 μg/mL exhibits the best biocompatibility with mice fibroblast cells (line L929). © 2011 Elsevier B.V.

KW - Graphene

KW - Graphene oxide

KW - In vitro toxicology

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M3 - RGC 21 - Publication in refereed journal

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JO - Colloids and Surfaces B: Biointerfaces

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Synthesis, dispersion, and cytocompatibility of graphene oxide and reduced graphene oxide

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