Synthesis, characterization and cytotoxicity of ammine/methylamine platinum (n) complexes with carboxylates

Seven novel platinum (H) complexes [Pt (II) (NH₃) (CH₃NH₂) X₂] (I-VII) (X: CH₃COO^-, CH₂ClOO^-, CHCl₂COO^-, C₆H₅-COO^-, p-CH₃O-C₆H₄-COO^-, p-NH₂- C₆H₄COO^-, p-NO₂-C₆H₄-COO^-) were prepared and characterized by means of elemental analysis, molar conductivity, thermal analysis, IR, UV, and ¹H NMR spectrometries. The cytotoxicity against HCT-8, BGC-823, MCF-7, EJ, and HL-60 cell lines increases in the following sequence: cisplatin > IV > V > VI > VII > I > II > III. Moreover, the complexes (I-VII) display substantially greater activities against EJ and HL-60 cell lines than those against the cell lines from other carcinomas. They can induce a concentration-dependent accumulation of HL-60 cells in the G₂/M phase of the cell cycle as cisplatin. There is no significant correlation between total DNA platination levels and cytotoxicity of the complexes.