Synthesis, characterization and cytotoxicity of ammine/methylamine platinum (n) complexes with carboxylates

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Original languageEnglish
Pages (from-to)278-282
Journal / PublicationChemical Research in Chinese Universities
Issue number3
Publication statusPublished - May 2006


Seven novel platinum (H) complexes [Pt (II) (NH3) (CH3NH2) X2] (I-VII) (X: CH3COO-, CH2ClOO-, CHCl2COO-, C6H5-COO-, p-CH3O-C6H4-COO-, p-NH2- C6H4COO-, p-NO2-C6H4-COO-) were prepared and characterized by means of elemental analysis, molar conductivity, thermal analysis, IR, UV, and 1H NMR spectrometries. The cytotoxicity against HCT-8, BGC-823, MCF-7, EJ, and HL-60 cell lines increases in the following sequence: cisplatin > IV > V > VI > VII > I > II > III. Moreover, the complexes (I-VII) display substantially greater activities against EJ and HL-60 cell lines than those against the cell lines from other carcinomas. They can induce a concentration-dependent accumulation of HL-60 cells in the G2/M phase of the cell cycle as cisplatin. There is no significant correlation between total DNA platination levels and cytotoxicity of the complexes.

Research Area(s)

  • Ammine/methylamine platinum (II) complex, Cell cycle, Cytotoxicity, DNA-binding, Synthesis