TY - JOUR
T1 - Synthesis, characterization and cytotoxicity of ammine/methylamine platinum (n) complexes with carboxylates
AU - Zhang, Jin-Chao
AU - Shen, Yong
AU - Yang, Meng-Su
PY - 2006/5
Y1 - 2006/5
N2 - Seven novel platinum (H) complexes [Pt (II) (NH3) (CH3NH2) X2] (I-VII) (X: CH3COO-, CH2ClOO-, CHCl2COO-, C6H5-COO-, p-CH3O-C6H4-COO-, p-NH2- C6H4COO-, p-NO2-C6H4-COO-) were prepared and characterized by means of elemental analysis, molar conductivity, thermal analysis, IR, UV, and 1H NMR spectrometries. The cytotoxicity against HCT-8, BGC-823, MCF-7, EJ, and HL-60 cell lines increases in the following sequence: cisplatin > IV > V > VI > VII > I > II > III. Moreover, the complexes (I-VII) display substantially greater activities against EJ and HL-60 cell lines than those against the cell lines from other carcinomas. They can induce a concentration-dependent accumulation of HL-60 cells in the G2/M phase of the cell cycle as cisplatin. There is no significant correlation between total DNA platination levels and cytotoxicity of the complexes.
AB - Seven novel platinum (H) complexes [Pt (II) (NH3) (CH3NH2) X2] (I-VII) (X: CH3COO-, CH2ClOO-, CHCl2COO-, C6H5-COO-, p-CH3O-C6H4-COO-, p-NH2- C6H4COO-, p-NO2-C6H4-COO-) were prepared and characterized by means of elemental analysis, molar conductivity, thermal analysis, IR, UV, and 1H NMR spectrometries. The cytotoxicity against HCT-8, BGC-823, MCF-7, EJ, and HL-60 cell lines increases in the following sequence: cisplatin > IV > V > VI > VII > I > II > III. Moreover, the complexes (I-VII) display substantially greater activities against EJ and HL-60 cell lines than those against the cell lines from other carcinomas. They can induce a concentration-dependent accumulation of HL-60 cells in the G2/M phase of the cell cycle as cisplatin. There is no significant correlation between total DNA platination levels and cytotoxicity of the complexes.
KW - Ammine/methylamine platinum (II) complex
KW - Cell cycle
KW - Cytotoxicity
KW - DNA-binding
KW - Synthesis
UR - http://www.scopus.com/inward/record.url?scp=33746594161&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-33746594161&origin=recordpage
U2 - 10.1016/S1005-9040(06)60098-6
DO - 10.1016/S1005-9040(06)60098-6
M3 - RGC 21 - Publication in refereed journal
SN - 1005-9040
VL - 22
SP - 278
EP - 282
JO - Chemical Research in Chinese Universities
JF - Chemical Research in Chinese Universities
IS - 3
ER -
