Synthesis, characterization and antitumor activities of new type platinum(II) complexes

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

2 Scopus Citations
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Author(s)

  • Jin-Chao Zhang
  • Yu-Qiu Gong
  • Xiao-Ming Zheng
  • Meng-Su Yang
  • Jing-Rong Cui

Detail(s)

Original languageEnglish
Pages (from-to)1752-1758
Journal / PublicationChinese Journal of Inorganic Chemistry
Volume21
Issue number11
Publication statusPublished - Nov 2005

Abstract

Seven novel platinum(II) complexes[Pt(II)(NH3)(H 2O)X](I-VII) {X=(COO-)2(oxalato), 2p-CH 3O-C6H4-COO- (p-methyoxbenzolato), 2C6H5-COO-(benzolato), 2CH3COO -(acetato), (CH2)2 (COO-) 2(malonato), (CH2)2(COO-) 2 (succinato), (CH=CH) (COO-)2(maleato)} have been prepared and characterized by elemental analysis, thermal analysis, IR, UV, and 1H NMR spectroscopy. The antitumor activities of these complexes in vitro against EJinput commasHCT-8, KB, BGC-823, Bel-7402, HL-60, MCF-7 and Hela cell lines have been studied. Complex I and V show remarkable antitumor activities against EJ cell line, and the inhibitory rate is 45.96% and 54.32% at concentration of 10 μmol·L-1, respectively. The inhibitory rate of the complexes II and III is greater than 50% against HL-60, BGC-823, KB and EJ cell lines. The inhibitory rate of the complex VI is 51.89% and 57.96% against BGC-823 and EJ cell lines. The complexes IV and VII have no antitumor activities against tested tumor cell lines. The complexes II, III and VI can stem the cell cycle of HL-60 on the G2+M.

Research Area(s)

  • Antitumor activity, Cell cycle, Classical structure-activity relationships, Platinum(II) complexes

Citation Format(s)

Synthesis, characterization and antitumor activities of new type platinum(II) complexes. / Zhang, Jin-Chao; Gong, Yu-Qiu; Zheng, Xiao-Ming et al.
In: Chinese Journal of Inorganic Chemistry, Vol. 21, No. 11, 11.2005, p. 1752-1758.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review