Synthesis, characterization and antiproliferative activity of platinum(II) complexes with 3-(2-pyridyl)-N1,2-methyl-1,2,4-triazoles

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

1 Scopus Citations
View graph of relations

Author(s)

  • Yulia M. Ohorodnik
  • Dmytro M. Khomenko
  • Roman O. Doroshchuk
  • Ilona V. Raspertova
  • Sergiu Shova
  • Miljan N.M. Milunovic
  • Rostyslav D. Lampeka

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number121646
Journal / PublicationInorganica Chimica Acta
Volume556
Online published25 Jun 2023
Publication statusPublished - 1 Oct 2023

Link(s)

Abstract

The present work describes the synthesis, investigation and in vitro cytotoxicity of Pt(II) complexes with 3-(2-pyridyl)-N1-methyl-1,2,4-triazole (L1) and 3-(2-pyridyl)–N2-methyl-1,2,4-triazole (L2). The crystal structures of PtL1Cl2 and PtL2Cl2 were established using X-Ray analysis, which revealed the square-planar PtN2Cl2 coordination geometry for the central metal ion. High-resolution mass spectrometry (HRMS), as well as one- and two-dimensional nuclear magnetic resonance (NMR) spectroscopy showed stability of the investigated complexes in DMF solution, in contrast to DMSO, where species were shown to partially dissociate. The cytotoxicity of the investigated compounds was determined by the colorimetric MTT assay against two human cancer cell lines, including cisplatin-sensitive human ovarian adenocarcinoma A2780 cells (IC50 = 26 ± 5 and 6.1 ± 0.6 for PtL1Cl2 and PtL2Cl2 correspondingly) and their cisplatin-resistant A2780cis analogue (IC50 = 24 ± 2 and 20 ± 3 for PtL1Cl2 and PtL2Cl2 correspondingly). © 2023 The Author(s)

Research Area(s)

  • 1, 2, 4-Triazole, Cisplatin, Crystal structures, NMR-spectroscopy, Platinum

Citation Format(s)

Synthesis, characterization and antiproliferative activity of platinum(II) complexes with 3-(2-pyridyl)-N1,2-methyl-1,2,4-triazoles. / Ohorodnik, Yulia M.; Khomenko, Dmytro M.; Doroshchuk, Roman O. et al.
In: Inorganica Chimica Acta, Vol. 556, 121646, 01.10.2023.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

Download Statistics

No data available