Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Kang Jin
  • Kathy Hiu Laam Po
  • Shengxi Wang
  • Jonathan Avraham Reuven
  • Chi Nga Wai
  • Ho Ting Lau
  • Ting Ho Chan
  • Xuechen Li

Detail(s)

Original languageEnglish
Pages (from-to)4990-4995
Journal / PublicationBioorganic and Medicinal Chemistry
Volume25
Issue number18
Online published29 Apr 2017
Publication statusPublished - 15 Sep 2017
Externally publishedYes

Abstract

Convergent Ser/Thr ligation has been used to prepare a series of teixobactin analogues (28 in total) to establish a structure-activity relationship of teixobactin. anti-bacterial evaluations of these synthetic analogues have revealed the critical amino acid residues and the sites tolerable of modifications. These studies will shed lights on the further development of teixobactin analogues with improved antibacterial activities.

Research Area(s)

  • SAR study, Ser/Thr ligation, Teixobactin analogues

Citation Format(s)

Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation. / Jin, Kang; Po, Kathy Hiu Laam; Wang, Shengxi; Reuven, Jonathan Avraham; Wai, Chi Nga; Lau, Ho Ting; Chan, Ting Ho; Chen, Sheng; Li, Xuechen.

In: Bioorganic and Medicinal Chemistry, Vol. 25, No. 18, 15.09.2017, p. 4990-4995.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal