Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation

Kang Jin; Kathy Hiu Laam Po; Shengxi Wang; Jonathan Avraham Reuven; Chi Nga Wai; Ho Ting Lau; Ting Ho Chan; Sheng Chen; Xuechen Li

doi:10.1016/j.bmc.2017.04.039

Author(s)

Kang Jin
Kathy Hiu Laam Po
Shengxi Wang
Jonathan Avraham Reuven
Chi Nga Wai
Ho Ting Lau
Ting Ho Chan
Xuechen Li

Detail(s)

Original language	English
Pages (from-to)	4990-4995
Journal / Publication	Bioorganic and Medicinal Chemistry
Volume	25
Issue number	18
Online published	29 Apr 2017
Publication status	Published - 15 Sep 2017
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1016/j.bmc.2017.04.039 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85019039913&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(f4b127b1-3a2f-44cf-927e-a33693bda899).html

Abstract

Convergent Ser/Thr ligation has been used to prepare a series of teixobactin analogues (28 in total) to establish a structure-activity relationship of teixobactin. anti-bacterial evaluations of these synthetic analogues have revealed the critical amino acid residues and the sites tolerable of modifications. These studies will shed lights on the further development of teixobactin analogues with improved antibacterial activities.

Research Area(s)

SAR study, Ser/Thr ligation, Teixobactin analogues

Citation Format(s)

[ RIS ] [ BibTeX ]

Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation. / Jin, Kang; Po, Kathy Hiu Laam; Wang, Shengxi; Reuven, Jonathan Avraham; Wai, Chi Nga; Lau, Ho Ting; Chan, Ting Ho; Chen, Sheng; Li, Xuechen.

In: Bioorganic and Medicinal Chemistry, Vol. 25, No. 18, 15.09.2017, p. 4990-4995.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal

Jin, K, Po, KHL, Wang, S, Reuven, JA, Wai, CN, Lau, HT, Chan, TH, Chen, S & Li, X 2017, 'Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation', Bioorganic and Medicinal Chemistry, vol. 25, no. 18, pp. 4990-4995. https://doi.org/10.1016/j.bmc.2017.04.039

Jin, K., Po, K. H. L., Wang, S., Reuven, J. A., Wai, C. N., Lau, H. T., Chan, T. H., Chen, S., & Li, X. (2017). Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation. Bioorganic and Medicinal Chemistry, 25(18), 4990-4995. https://doi.org/10.1016/j.bmc.2017.04.039

Jin K, Po KHL, Wang S, Reuven JA, Wai CN, Lau HT et al. Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation. Bioorganic and Medicinal Chemistry. 2017 Sep 15;25(18):4990-4995. https://doi.org/10.1016/j.bmc.2017.04.039

Jin, Kang ; Po, Kathy Hiu Laam ; Wang, Shengxi ; Reuven, Jonathan Avraham ; Wai, Chi Nga ; Lau, Ho Ting ; Chan, Ting Ho ; Chen, Sheng ; Li, Xuechen. / Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation. In: Bioorganic and Medicinal Chemistry. 2017 ; Vol. 25, No. 18. pp. 4990-4995.