Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Pages (from-to) | 4990-4995 |
Journal / Publication | Bioorganic and Medicinal Chemistry |
Volume | 25 |
Issue number | 18 |
Online published | 29 Apr 2017 |
Publication status | Published - 15 Sep 2017 |
Externally published | Yes |
Link(s)
Abstract
Convergent Ser/Thr ligation has been used to prepare a series of teixobactin analogues (28 in total) to establish a structure-activity relationship of teixobactin. anti-bacterial evaluations of these synthetic analogues have revealed the critical amino acid residues and the sites tolerable of modifications. These studies will shed lights on the further development of teixobactin analogues with improved antibacterial activities.
Research Area(s)
- SAR study, Ser/Thr ligation, Teixobactin analogues
Citation Format(s)
Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation. / Jin, Kang; Po, Kathy Hiu Laam; Wang, Shengxi; Reuven, Jonathan Avraham; Wai, Chi Nga; Lau, Ho Ting; Chan, Ting Ho; Chen, Sheng; Li, Xuechen.
In: Bioorganic and Medicinal Chemistry, Vol. 25, No. 18, 15.09.2017, p. 4990-4995.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review