Synthesis and in vitro photodynamic activity of mono-substituted amphiphilic zinc(II) phthalocyanines

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Baozhong Zhao
  • Wubiao Duan
  • Wing-Ping Fong
  • Wing-Hung Ko
  • Dennis K.P. Ng

Detail(s)

Original languageEnglish
Pages (from-to)1073-1077
Journal / PublicationBioorganic and Medicinal Chemistry Letters
Volume17
Issue number4
Publication statusPublished - 15 Feb 2007
Externally publishedYes

Abstract

A series of novel zinc(II) phthalocyanines mono-substituted with a 1,3-bis(dimethylamino)-2-propoxy group at the α- or β-position, and the corresponding di-N-methylated derivatives, have been synthesized. All these compounds can generate singlet oxygen effectively and exhibit high in vitro photodynamic activities toward HT29 human colorectal carcinoma cells with IC50 values down to 0.08 μM. The dicationic derivatives have a higher affinity to the cell membrane compared with the non-ionic counterparts. © 2006 Elsevier Ltd. All rights reserved.

Research Area(s)

  • Colorectal carcinoma, Photodynamic therapy, Photosensitizers, Phthalocyanines

Citation Format(s)

Synthesis and in vitro photodynamic activity of mono-substituted amphiphilic zinc(II) phthalocyanines. / Lo, Pui-Chi; Zhao, Baozhong; Duan, Wubiao; Fong, Wing-Ping; Ko, Wing-Hung; Ng, Dennis K.P.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 17, No. 4, 15.02.2007, p. 1073-1077.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal