Synthesis and in vitro photodynamic activity of mono-substituted amphiphilic zinc(II) phthalocyanines

Pui-Chi Lo; Baozhong Zhao; Wubiao Duan; Wing-Ping Fong; Wing-Hung Ko; Dennis K.P. Ng

doi:10.1016/j.bmcl.2006.11.017

Synthesis and in vitro photodynamic activity of mono-substituted amphiphilic zinc(II) phthalocyanines

Pui-Chi Lo
, Baozhong Zhao
, Wubiao Duan
, Wing-Ping Fong
, Wing-Hung Ko
, Dennis K.P. Ng

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

29 Citations (Scopus)

Abstract

A series of novel zinc(II) phthalocyanines mono-substituted with a 1,3-bis(dimethylamino)-2-propoxy group at the α- or β-position, and the corresponding di-N-methylated derivatives, have been synthesized. All these compounds can generate singlet oxygen effectively and exhibit high in vitro photodynamic activities toward HT29 human colorectal carcinoma cells with IC₅₀ values down to 0.08 μM. The dicationic derivatives have a higher affinity to the cell membrane compared with the non-ionic counterparts. © 2006 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	1073-1077
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.bmcl.2006.11.017
Publication status	Published - 15 Feb 2007
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Colorectal carcinoma
Photodynamic therapy
Photosensitizers
Phthalocyanines

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10.1016/j.bmcl.2006.11.017

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title = "Synthesis and in vitro photodynamic activity of mono-substituted amphiphilic zinc(II) phthalocyanines",

abstract = "A series of novel zinc(II) phthalocyanines mono-substituted with a 1,3-bis(dimethylamino)-2-propoxy group at the α- or β-position, and the corresponding di-N-methylated derivatives, have been synthesized. All these compounds can generate singlet oxygen effectively and exhibit high in vitro photodynamic activities toward HT29 human colorectal carcinoma cells with IC50 values down to 0.08 μM. The dicationic derivatives have a higher affinity to the cell membrane compared with the non-ionic counterparts. {\textcopyright} 2006 Elsevier Ltd. All rights reserved.",

keywords = "Colorectal carcinoma, Photodynamic therapy, Photosensitizers, Phthalocyanines",

author = "Pui-Chi Lo and Baozhong Zhao and Wubiao Duan and Wing-Ping Fong and Wing-Hung Ko and Ng, \{Dennis K.P.\}",

year = "2007",

month = feb,

day = "15",

doi = "10.1016/j.bmcl.2006.11.017",

language = "English",

volume = "17",

pages = "1073--1077",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "4",

}

TY - JOUR

T1 - Synthesis and in vitro photodynamic activity of mono-substituted amphiphilic zinc(II) phthalocyanines

AU - Lo, Pui-Chi

AU - Zhao, Baozhong

AU - Duan, Wubiao

AU - Fong, Wing-Ping

AU - Ko, Wing-Hung

AU - Ng, Dennis K.P.

PY - 2007/2/15

Y1 - 2007/2/15

N2 - A series of novel zinc(II) phthalocyanines mono-substituted with a 1,3-bis(dimethylamino)-2-propoxy group at the α- or β-position, and the corresponding di-N-methylated derivatives, have been synthesized. All these compounds can generate singlet oxygen effectively and exhibit high in vitro photodynamic activities toward HT29 human colorectal carcinoma cells with IC50 values down to 0.08 μM. The dicationic derivatives have a higher affinity to the cell membrane compared with the non-ionic counterparts. © 2006 Elsevier Ltd. All rights reserved.

AB - A series of novel zinc(II) phthalocyanines mono-substituted with a 1,3-bis(dimethylamino)-2-propoxy group at the α- or β-position, and the corresponding di-N-methylated derivatives, have been synthesized. All these compounds can generate singlet oxygen effectively and exhibit high in vitro photodynamic activities toward HT29 human colorectal carcinoma cells with IC50 values down to 0.08 μM. The dicationic derivatives have a higher affinity to the cell membrane compared with the non-ionic counterparts. © 2006 Elsevier Ltd. All rights reserved.

KW - Colorectal carcinoma

KW - Photodynamic therapy

KW - Photosensitizers

KW - Phthalocyanines

UR - https://www.scopus.com/pages/publications/33846569353

UR - https://www.scopus.com/pages/publications/33846569353#tab=impact

U2 - 10.1016/j.bmcl.2006.11.017

DO - 10.1016/j.bmcl.2006.11.017

M3 - RGC 21 - Publication in refereed journal

C2 - 17127058

SN - 0960-894X

VL - 17

SP - 1073

EP - 1077

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

ER -

Synthesis and in vitro photodynamic activity of mono-substituted amphiphilic zinc(II) phthalocyanines

Abstract

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