Synthesis and in vitro photodynamic activities of pegylated distyryl boron dipyrromethene derivatives

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Hui He
  • Pui-Chi Lo
  • Sin-Lui Yeung
  • Wing-Ping Fong
  • Dennis K. P. Ng

Detail(s)

Original languageEnglish
Pages (from-to)3097-3102
Journal / PublicationJournal of Medicinal Chemistry
Volume54
Issue number8
Publication statusPublished - 28 Apr 2011
Externally publishedYes

Abstract

A series of pegylated distyryl boron dipyrromethenes have been prepared and characterized. Their in vitro photodynamic activities in Tween 80 emulsions have also been investigated against HT29 human colorectal carcinoma cells. The derivative having five triethylene glycol chains (compound 8) exhibits the highest photocytotoxicity with an IC50 as low as 7 nM. It is also localized preferentially in the endoplasmic reticulum of the cells and can induce predominately apoptosis upon illumination. © 2011 American Chemical Society.

Citation Format(s)

Synthesis and in vitro photodynamic activities of pegylated distyryl boron dipyrromethene derivatives. / He, Hui; Lo, Pui-Chi; Yeung, Sin-Lui; Fong, Wing-Ping; Ng, Dennis K. P.

In: Journal of Medicinal Chemistry, Vol. 54, No. 8, 28.04.2011, p. 3097-3102.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal