Synthesis and in vitro photodynamic activities of pegylated distyryl boron dipyrromethene derivatives

Hui He; Pui-Chi Lo; Sin-Lui Yeung; Wing-Ping Fong; Dennis K. P. Ng

doi:10.1021/jm101637g

Author(s)

Hui He
Pui-Chi Lo
Sin-Lui Yeung
Wing-Ping Fong
Dennis K. P. Ng

Detail(s)

Original language	English
Pages (from-to)	3097-3102
Journal / Publication	Journal of Medicinal Chemistry
Volume	54
Issue number	8
Publication status	Published - 28 Apr 2011
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1021/jm101637g Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-79955461251&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(3f2505d5-bb12-4977-8ff9-0ab9c6590c5c).html

Abstract

A series of pegylated distyryl boron dipyrromethenes have been prepared and characterized. Their in vitro photodynamic activities in Tween 80 emulsions have also been investigated against HT29 human colorectal carcinoma cells. The derivative having five triethylene glycol chains (compound 8) exhibits the highest photocytotoxicity with an IC₅₀ as low as 7 nM. It is also localized preferentially in the endoplasmic reticulum of the cells and can induce predominately apoptosis upon illumination. © 2011 American Chemical Society.

Citation Format(s)

[ RIS ] [ BibTeX ]

Synthesis and in vitro photodynamic activities of pegylated distyryl boron dipyrromethene derivatives. / He, Hui; Lo, Pui-Chi; Yeung, Sin-Lui et al.
In: Journal of Medicinal Chemistry, Vol. 54, No. 8, 28.04.2011, p. 3097-3102.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

He, H, Lo, P-C, Yeung, S-L, Fong, W-P & Ng, DKP 2011, 'Synthesis and in vitro photodynamic activities of pegylated distyryl boron dipyrromethene derivatives', Journal of Medicinal Chemistry, vol. 54, no. 8, pp. 3097-3102. https://doi.org/10.1021/jm101637g

He, H., Lo, P-C., Yeung, S-L., Fong, W-P., & Ng, D. K. P. (2011). Synthesis and in vitro photodynamic activities of pegylated distyryl boron dipyrromethene derivatives. Journal of Medicinal Chemistry, 54(8), 3097-3102. https://doi.org/10.1021/jm101637g

He H, Lo P-C, Yeung S-L, Fong W-P, Ng DKP. Synthesis and in vitro photodynamic activities of pegylated distyryl boron dipyrromethene derivatives. Journal of Medicinal Chemistry. 2011 Apr 28;54(8):3097-3102. doi: 10.1021/jm101637g

He, Hui ; Lo, Pui-Chi ; Yeung, Sin-Lui et al. / Synthesis and in vitro photodynamic activities of pegylated distyryl boron dipyrromethene derivatives. In: Journal of Medicinal Chemistry. 2011 ; Vol. 54, No. 8. pp. 3097-3102.