Synthesis and in vitro photodynamic activities of pegylated distyryl boron dipyrromethene derivatives

Hui He; Pui-Chi Lo; Sin-Lui Yeung; Wing-Ping Fong; Dennis K. P. Ng

doi:10.1021/jm101637g

Synthesis and in vitro photodynamic activities of pegylated distyryl boron dipyrromethene derivatives

Hui He, Pui-Chi Lo, Sin-Lui Yeung, Wing-Ping Fong, Dennis K. P. Ng

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

67 Citations (Scopus)

Abstract

A series of pegylated distyryl boron dipyrromethenes have been prepared and characterized. Their in vitro photodynamic activities in Tween 80 emulsions have also been investigated against HT29 human colorectal carcinoma cells. The derivative having five triethylene glycol chains (compound 8) exhibits the highest photocytotoxicity with an IC₅₀ as low as 7 nM. It is also localized preferentially in the endoplasmic reticulum of the cells and can induce predominately apoptosis upon illumination. © 2011 American Chemical Society.

Original language	English
Pages (from-to)	3097-3102
Journal	Journal of Medicinal Chemistry
Volume	54
Issue number	8
DOIs	https://doi.org/10.1021/jm101637g
Publication status	Published - 28 Apr 2011
Externally published	Yes

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abstract = "A series of pegylated distyryl boron dipyrromethenes have been prepared and characterized. Their in vitro photodynamic activities in Tween 80 emulsions have also been investigated against HT29 human colorectal carcinoma cells. The derivative having five triethylene glycol chains (compound 8) exhibits the highest photocytotoxicity with an IC50 as low as 7 nM. It is also localized preferentially in the endoplasmic reticulum of the cells and can induce predominately apoptosis upon illumination. {\textcopyright} 2011 American Chemical Society.",

author = "Hui He and Pui-Chi Lo and Sin-Lui Yeung and Wing-Ping Fong and Ng, {Dennis K. P.}",

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T1 - Synthesis and in vitro photodynamic activities of pegylated distyryl boron dipyrromethene derivatives

AU - He, Hui

AU - Lo, Pui-Chi

AU - Yeung, Sin-Lui

AU - Fong, Wing-Ping

AU - Ng, Dennis K. P.

PY - 2011/4/28

Y1 - 2011/4/28

N2 - A series of pegylated distyryl boron dipyrromethenes have been prepared and characterized. Their in vitro photodynamic activities in Tween 80 emulsions have also been investigated against HT29 human colorectal carcinoma cells. The derivative having five triethylene glycol chains (compound 8) exhibits the highest photocytotoxicity with an IC50 as low as 7 nM. It is also localized preferentially in the endoplasmic reticulum of the cells and can induce predominately apoptosis upon illumination. © 2011 American Chemical Society.

AB - A series of pegylated distyryl boron dipyrromethenes have been prepared and characterized. Their in vitro photodynamic activities in Tween 80 emulsions have also been investigated against HT29 human colorectal carcinoma cells. The derivative having five triethylene glycol chains (compound 8) exhibits the highest photocytotoxicity with an IC50 as low as 7 nM. It is also localized preferentially in the endoplasmic reticulum of the cells and can induce predominately apoptosis upon illumination. © 2011 American Chemical Society.

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U2 - 10.1021/jm101637g

DO - 10.1021/jm101637g

M3 - RGC 21 - Publication in refereed journal

C2 - 21417218

SN - 0022-2623

VL - 54

SP - 3097

EP - 3102

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 8

ER -

Synthesis and in vitro photodynamic activities of pegylated distyryl boron dipyrromethene derivatives

Abstract

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