TY - JOUR
T1 - Synthesis and hydrothermal treatment of nanostructured hydroxyapatite of controllable sizes
AU - Loo, Say Chye Joachim
AU - Siew, Yiwei Eva
AU - Ho, Shuhui
AU - Boey, Freddy Yin Chiang
AU - Ma, J.
PY - 2008/3
Y1 - 2008/3
N2 - Nanoparticulate systems have been studied for targeted and controlled release of therapeutic agents; and size is one of the major determinants of their in vivo clearance kinetics by the MPS macrophages. As such, it is important to control the size of hydroxyapatite nanoparticles during synthesis. The results show that the size of hydroxyapatite nanoparticles, synthesized through chemical precipitation, increases with increasing synthesis time. Particle sizes were also observed to increase in a linear correlation with temperature. Crystallinity and carbonate-substitution of the nanoparticles also increased with temperature. Hydrothermal, performed as a post-synthesis treatment, improves particle morphology, giving particles with regular surface contours, well-defined sizes and lower particle agglomeration. By controlling synthesis temperature and time, hydroxyapatite nanoparticles with well-defined sizes and morphology can be obtained. © Springer Science+Business Media, LLC 2007.
AB - Nanoparticulate systems have been studied for targeted and controlled release of therapeutic agents; and size is one of the major determinants of their in vivo clearance kinetics by the MPS macrophages. As such, it is important to control the size of hydroxyapatite nanoparticles during synthesis. The results show that the size of hydroxyapatite nanoparticles, synthesized through chemical precipitation, increases with increasing synthesis time. Particle sizes were also observed to increase in a linear correlation with temperature. Crystallinity and carbonate-substitution of the nanoparticles also increased with temperature. Hydrothermal, performed as a post-synthesis treatment, improves particle morphology, giving particles with regular surface contours, well-defined sizes and lower particle agglomeration. By controlling synthesis temperature and time, hydroxyapatite nanoparticles with well-defined sizes and morphology can be obtained. © Springer Science+Business Media, LLC 2007.
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U2 - 10.1007/s10856-007-3261-9
DO - 10.1007/s10856-007-3261-9
M3 - RGC 21 - Publication in refereed journal
C2 - 17914615
SN - 0957-4530
VL - 19
SP - 1389
EP - 1397
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
IS - 3
ER -