Synthesis and evaluation of biological activity of homodrimane sesquiterpenoids bearing hydrazinecarbothioamide or 1,2,4-triazole unit

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

7 Scopus Citations
View graph of relations

Author(s)

  • Lidia Lungu
  • Alexandru Ciocarlan
  • Alic Barba
  • Sergiu Shova
  • Serghei Pogrebnoi
  • Ionel Mangalagiu
  • Costel Moldoveanu
  • Nicoleta Vornicu
  • Michele D’Ambrosio
  • Vladimir B. Arion
  • Aculina Aricu

Detail(s)

Original languageEnglish
Pages (from-to)716-724
Journal / PublicationChemistry of Heterocyclic Compounds
Volume55
Issue number8
Online published20 Aug 2019
Publication statusPublished - Aug 2019
Externally publishedYes

Abstract

Synthesis of novel (+)-sclareolide-based homodrimane sesquiterpenoids bearing hydrazinecarbothioamide or N-substituted 1,2,4-triazole unit has been reported. These heterocyclic compounds demonstrate promising in vitro antifungal and antibacterial activities toward fungal species Aspergillus niger, Fusarium solani, Penicillium chrysogenum, Penicillium frequentans, and Alternaria alternata and bacteria strains Bacillus sp. and Pseudomonas aeruginosa at minimum inhibitory concentration level of μg/ml. In addition, two homodrimane sesquiterpenoids with hydrazinecarbothioamide fragment show cytotoxicity toward human ovarian carcinoma cells A2780 and A2780cis with half maximal inhibitory concentration values in range of 9–15 μM.

Research Area(s)

  • 1,2,4-triazole, antibacterial activity, anticancer activity, antifungal activity, homodrimane sesquiterpenoid, hydrazinecarbothioamide, microwave irradiation

Citation Format(s)

Synthesis and evaluation of biological activity of homodrimane sesquiterpenoids bearing hydrazinecarbothioamide or 1,2,4-triazole unit. / Lungu, Lidia; Ciocarlan, Alexandru; Barba, Alic et al.

In: Chemistry of Heterocyclic Compounds, Vol. 55, No. 8, 08.2019, p. 716-724.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review