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Synovium-derived mesenchymal stem cells: A new cell source for musculoskeletal regeneration

  • Jiabing Fan
  • , Rohan R. Varshney
  • , Li Ren
  • , Daozhang Cai*
  • , Dong-An Wang*
  • *Corresponding author for this work

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

Abstract

Ever since synovium-derived mesenchymal stem cells (SMSCs) were first identified and successfully isolated in 2001, as a brand new member in MSC families, they have been increasingly regarded as a promising therapeutic cell species for musculoskeletal regeneration, particularly for reconstructions of cartilage, bones, tendons, and muscles. Besides the general multipotency in common among the MSC community, SMSCs excel other sourced MSCs in higher ability of proliferation and superiority in chondrogenesis. This review summarizes the latest advances in SMSC-related studies covering their specific isolation methodologies, biological insights, and practical applications in musculoskeletal therapeutics of which an emphasis is cast on engineered chondrogenesis. © 2009 Mary Ann Liebert, Inc.
Original languageEnglish
Pages (from-to)75-86
JournalTissue Engineering - Part B: Reviews
Volume15
Issue number1
DOIs
Publication statusPublished - 1 Mar 2009
Externally publishedYes

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