Synergistic treatment of ovarian cancer by co-delivery of survivin shRNA and paclitaxel via supramolecular micellar assembly

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

104 Scopus Citations
View graph of relations

Author(s)

  • Qinglian Hu
  • Wen Li
  • Xiurong Hu
  • Qida Hu
  • Jie Shen
  • Xue Jin
  • Jun Zhou
  • Guping Tang

Detail(s)

Original languageEnglish
Pages (from-to)6580-6591
Journal / PublicationBiomaterials
Volume33
Issue number27
Publication statusPublished - Sep 2012

Abstract

Non-viral gene-delivery platforms have been developed to co-deliver chemotherapeutics and siRNAs. The synergistic effects between shRNAs against survivin and Paclitaxel (PTX) using supramolecular micelles self-assembled from the host PEI-CyD (PC) composed of β-cyclodextrin (β-CyD) and polyethylenimine (PEI, Mw 600) and guest adamantine conjugated PTX (Ada-PTX) in combination cancer therapy are investigated. The Ada-PTX is encapsulated inside the core and shRNA sticks to the shell surface. The physicochemical properties of these supramolecular nanoparticles are favorable to cell uptake and intracellular trafficking. Moreover, PTX and shRNA simultaneously delivered to SKOV-3 cells lead to efficient reduction in the survivin and Bcl-2 expression as well as synergistic cell apoptotic induction in the in vitro study. In particular, co-delivery of survivin shRNA and PTX suppresses cancer growth more effectively than delivery of either paclitaxel or shRNA in ovarian cancer therapy. © 2012 Elsevier Ltd.

Research Area(s)

  • Cancer treatment, Paclitaxel, SiRNA, Supramolecular micelles

Citation Format(s)

Synergistic treatment of ovarian cancer by co-delivery of survivin shRNA and paclitaxel via supramolecular micellar assembly. / Hu, Qinglian; Li, Wen; Hu, Xiurong; Hu, Qida; Shen, Jie; Jin, Xue; Zhou, Jun; Tang, Guping; Chu, Paul K.

In: Biomaterials, Vol. 33, No. 27, 09.2012, p. 6580-6591.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review