Switchable Photoacoustic Imaging of Glutathione Using MnO2 Nanotubes for Cancer Diagnosis

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

1 Scopus Citations
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Author(s)

  • Chang Liu
  • Depeng Wang
  • Ye Zhan
  • Lingyue Yan
  • Qian Lu
  • Michael Yu Zarng Chang
  • Jingwen Luo
  • Dan Du
  • Yuehe Lin
  • Jun Xia
  • Yun Wu

Detail(s)

Original languageEnglish
Pages (from-to)44231-44239
Journal / PublicationACS Applied Materials and Interfaces
Volume10
Issue number51
Online published30 Nov 2018
Publication statusPublished - 26 Dec 2018

Abstract

Glutathione is overexpressed in tumor cells and regulates cancer growth, metastasis, and drug resistance. Therefore, detecting glutathione levels may greatly facilitate cancer diagnosis and treatment response monitoring. Photoacoustic (PA) imaging is a noninvasive modality for high-sensitivity, high-resolution, deep-tissue optical imaging. Switchable PA probes that offer signal on/off responses to tumor targets would further improve the detection sensitivity and signal-to-noise ratio of PA imaging. Here, we explore the use of MnO2 nanotubes as a switchable and biodegradable PA probe for dynamic imaging of glutathione in cancer. Glutathione reduces black MnO2 nanotubes into colorless Mn2+ ions, leading to decreased and signal off PA amplitude. In phantoms, we observed a linear response of reduced PA signals of MnO2 nanotubes to increased glutathione concentrations. Using melanoma as the disease model, we demonstrated that MnO2 nanotube-based PA imaging of glutathione successfully distinguished B16F10 melanoma cells from BEAS-2B normal cells and discriminated B16F10 tumors from healthy skin tissues. Our results showed that MnO2 nanotubes are a potent switchable and biodegradable PA probe for glutathione imaging in cancer diagnosis.

Research Area(s)

  • photoacoustic imaging, switchable contrast reagent, glutathione, MnO2, nanotubes, cancer, melanoma

Citation Format(s)

Switchable Photoacoustic Imaging of Glutathione Using MnO2 Nanotubes for Cancer Diagnosis. / Liu, Chang; Wang, Depeng; Zhan, Ye; Yan, Lingyue; Lu, Qian; Chang, Michael Yu Zarng; Luo, Jingwen; Wang, Lidai; Du, Dan; Lin, Yuehe; Xia, Jun; Wu, Yun.

In: ACS Applied Materials and Interfaces, Vol. 10, No. 51, 26.12.2018, p. 44231-44239.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review