Sutureless transplantation of in vivo priming human mesenchymal stem cell sheet promotes the therapeutic potential for cardiac repair

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Andrew Choi
  • Hyeok Kim
  • Hyeonseok Han
  • Jae-Hyun Park
  • Jin-Ju Kim
  • Woo-Sup Sim
  • Seong Jin Lee
  • Hun-Jun Park
  • Dong Sung Kim

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number015009
Journal / PublicationBiofabrication
Volume15
Issue number1
Online published27 Oct 2022
Publication statusPublished - 2023

Abstract

The heart, contrary to its small size, vigorously pumps oxygen and nutrients to our entire body indeterminably; and thus, its dysfunction could be devastating. Until now, there ave been several major obstacles to applying a cardiac patch for the treatment for myocardial infarction, including poor integration and low engraftment rates, due to the highly-curved surface of the heart and its dynamic nature. Here, we demonstrate a novel way for a comprehensive cardiac repair achieved by the sutureless transplantation of a highly integrable in vivo priming bone marrow mesenchymal stem cell (BMSC) sheet based on the utilization of a highly aligned thermoresponsive nanofiber membrane. Moreover, we developed a BMSC sheet specialized for vascular regeneration through 'in-vivo priming' using human umbilical vein endothelial cells. A prolonged secretion of multiple angiogenic cytokines, such as vascular endothelial growth factor, angiopoietin-1, insulin-like growth factor-1, which was observed in vitro from the specialized BMSC sheet seemed to lead a significant improvement in the cardiac function, including intrinsic contractibility and remodeling. In this study, we provide strong evidence that in vivo priming of a human BMSC sheet develops the therapeutic potential for cardiac repair.

Research Area(s)

  • cardiac repair, in vivo priming, nanofiber membrane, poly (N-isopropylacrylamide), stem cell, sutureless-transplantation

Citation Format(s)

Sutureless transplantation of in vivo priming human mesenchymal stem cell sheet promotes the therapeutic potential for cardiac repair. / Choi, Andrew; Kim, Hyeok; Han, Hyeonseok et al.
In: Biofabrication, Vol. 15, No. 1, 015009, 2023.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review