Projects per year
Abstract
The heart, contrary to its small size, vigorously pumps oxygen and nutrients to our entire body indeterminably; and thus, its dysfunction could be devastating. Until now, there ave been several major obstacles to applying a cardiac patch for the treatment for myocardial infarction, including poor integration and low engraftment rates, due to the highly-curved surface of the heart and its dynamic nature. Here, we demonstrate a novel way for a comprehensive cardiac repair achieved by the sutureless transplantation of a highly integrable in vivo priming bone marrow mesenchymal stem cell (BMSC) sheet based on the utilization of a highly aligned thermoresponsive nanofiber membrane. Moreover, we developed a BMSC sheet specialized for vascular regeneration through 'in-vivo priming' using human umbilical vein endothelial cells. A prolonged secretion of multiple angiogenic cytokines, such as vascular endothelial growth factor, angiopoietin-1, insulin-like growth factor-1, which was observed in vitro from the specialized BMSC sheet seemed to lead a significant improvement in the cardiac function, including intrinsic contractibility and remodeling. In this study, we provide strong evidence that in vivo priming of a human BMSC sheet develops the therapeutic potential for cardiac repair.
Original language | English |
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Article number | 015009 |
Journal | Biofabrication |
Volume | 15 |
Issue number | 1 |
Online published | 27 Oct 2022 |
DOIs | |
Publication status | Published - 2023 |
Research Keywords
- cardiac repair
- in vivo priming
- nanofiber membrane
- poly (N-isopropylacrylamide)
- stem cell
- sutureless-transplantation
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ASDC_Sub: Develop of Novel Method to Generate Mature Cardiomyocytes Derived from Human Pluripotent Stem Cells
BAN, K. (Principal Investigator / Project Coordinator)
1/02/21 → …
Project: Research