Sutureless transplantation of in vivo priming human mesenchymal stem cell sheet promotes the therapeutic potential for cardiac repair

Andrew Choi, Hyeok Kim, Hyeonseok Han, Jae-Hyun Park, Jin-Ju Kim, Woo-Sup Sim, Seong Jin Lee, Kiwon Ban*, Hun-Jun Park*, Dong Sung Kim*

*Corresponding author for this work

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

12 Citations (Scopus)

Abstract

The heart, contrary to its small size, vigorously pumps oxygen and nutrients to our entire body indeterminably; and thus, its dysfunction could be devastating. Until now, there ave been several major obstacles to applying a cardiac patch for the treatment for myocardial infarction, including poor integration and low engraftment rates, due to the highly-curved surface of the heart and its dynamic nature. Here, we demonstrate a novel way for a comprehensive cardiac repair achieved by the sutureless transplantation of a highly integrable in vivo priming bone marrow mesenchymal stem cell (BMSC) sheet based on the utilization of a highly aligned thermoresponsive nanofiber membrane. Moreover, we developed a BMSC sheet specialized for vascular regeneration through 'in-vivo priming' using human umbilical vein endothelial cells. A prolonged secretion of multiple angiogenic cytokines, such as vascular endothelial growth factor, angiopoietin-1, insulin-like growth factor-1, which was observed in vitro from the specialized BMSC sheet seemed to lead a significant improvement in the cardiac function, including intrinsic contractibility and remodeling. In this study, we provide strong evidence that in vivo priming of a human BMSC sheet develops the therapeutic potential for cardiac repair.
Original languageEnglish
Article number015009
JournalBiofabrication
Volume15
Issue number1
Online published27 Oct 2022
DOIs
Publication statusPublished - 2023

Research Keywords

  • cardiac repair
  • in vivo priming
  • nanofiber membrane
  • poly (N-isopropylacrylamide)
  • stem cell
  • sutureless-transplantation

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