Sustained releasing sponge-like 3D scaffolds for bone tissue engineering applications

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

6 Scopus Citations
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Author(s)

  • Vidya N Chamundeswari
  • Lui Yuan Siang
  • Yon Jin Chuah
  • Jing Shi Tan
  • Say Chye Joachim Loo

Detail(s)

Original languageEnglish
Article number015019
Journal / PublicationBiomedical Materials (Bristol)
Volume13
Issue number1
Online published28 Dec 2017
Publication statusPublished - Jan 2018
Externally publishedYes

Abstract

Tissue engineering (TE) is envisaged to play a vital role in improving quality of life by restoring, maintaining or enhancing tissue and organ functions. TE scaffolds that are two-dimensional in structure suffer from undesirable issues, such as pore blockage, and do not closely mimic the native extra-cellular matrix in tissues. Significant efforts have therefore been channeled to fabricate three-dimensional (3D) scaffolds using various techniques, especially electrospinning. In this study, we propose a modified one-step electrospinning process to arrive at a 3D scaffold with highly interconnected pores. Using a blend of poly (L-lactide)/polycaprolactone/poly (ethylene oxide), this mechanically viable, sponge-like 3D scaffold exhibited sufficiently large pores and enabled cell penetration beyond 500 μm. Dexamethasone (Dex) was loaded into the fibers and a sustained drug release was achieved. Further, the potential of this Dex-loaded 3D scaffold was evaluated for upregulation of osteogenic genes with mesenchymal stem cells. The as-produced Dex-loaded 3D scaffold possesses a unique intertwined sub-micron fibrous morphology that can be tailored for use in bone tissue engineering and beyond.

Research Area(s)

  • biodegradable polymers, long term drug release, spongy scaffold, stem cell differentiation

Citation Format(s)

Sustained releasing sponge-like 3D scaffolds for bone tissue engineering applications. / Chamundeswari, Vidya N; Yuan Siang, Lui; Jin Chuah, Yon; Shi Tan, Jing; Wang, Dong-An; Loo, Say Chye Joachim.

In: Biomedical Materials (Bristol), Vol. 13, No. 1, 015019, 01.2018.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review