Suppression of composite nanoparticle aggregation through steric stabilization and ligand exchange for colorimetric protein detection

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

11 Scopus Citations
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Author(s)

  • Dong Yang
  • Jianzhong Ma
  • Min Gao
  • Mingli Peng
  • Yanling Luo
  • Wenli Hui
  • Chao Chen
  • Yali Cui

Detail(s)

Original languageEnglish
Pages (from-to)9681-9686
Journal / PublicationRSC Advances
Volume3
Issue number25
Publication statusPublished - 7 Jul 2013

Abstract

Composite Fe3O4/Au nanoparticles are attracting considerable interest in nanomedicine due to their unique physical and chemical properties. However, successful applications of these particles are generally limited by their severe aggregation due to their ionic instability under physiological conditions. Here, by harnessing the steric stabilization and chemical ligand synergistic cooperation, we demonstrated that composite Fe 3O4/Au nanoparticles exhibited desirable colloidal stability, dispersity and functionalities in a wide range of pH values, rendering visual and specific detection of biomolecules of interest without using complex fluid handling and detection instruments. We envision that these novel composite nanoparticles might serve as ideal probes for real time, point of care diagnostics and therapy in resource-poor settings. © 2013 The Royal Society of Chemistry.

Citation Format(s)

Suppression of composite nanoparticle aggregation through steric stabilization and ligand exchange for colorimetric protein detection. / Yang, Dong; Ma, Jianzhong; Gao, Min; Peng, Mingli; Luo, Yanling; Hui, Wenli; Chen, Chao; Wang, Zuankai; Cui, Yali.

In: RSC Advances, Vol. 3, No. 25, 07.07.2013, p. 9681-9686.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review