Supercharged green fluorescent proteins as bimodal reporter genes for CEST MRI and optical imaging

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Detail(s)

Original languageEnglish
Pages (from-to)4869-4871
Journal / PublicationChemical Communications
Volume51
Issue number23
Publication statusPublished - 21 Mar 2015
Externally publishedYes

Abstract

Superpositively charged mutants of green fluorescent protein (GFP) demonstrated a dramatically improved chemical exchange saturation transfer (CEST) MRI contrast compared to their wild type counterparts. The mutants +36 GFP and +48 GFP were successfully expressed in mammalian cells and retained part of their fluorescence, making them a new potential bimodal reporter gene.

Citation Format(s)

Supercharged green fluorescent proteins as bimodal reporter genes for CEST MRI and optical imaging. / Bar-Shir, Amnon; Liang, Yajie; Chan, Kannie W. Y.; Gilad, Assaf A.; Bulte, Jeff W. M.

In: Chemical Communications, Vol. 51, No. 23, 21.03.2015, p. 4869-4871.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal