Suction-type microfluidic immunomagnetic bead-based system for rapid detection of influenza infection

Tze-Bin Huang; Lien-Yu Hung; Yi-Che Tsai; Chen-Sheng Yeh; Huan-Yao Lei; Gwo-Bin Lee

Suction-type microfluidic immunomagnetic bead-based system for rapid detection of influenza infection

Tze-Bin Huang
, Lien-Yu Hung
, Yi-Che Tsai
, Chen-Sheng Yeh
, Huan-Yao Lei
, Gwo-Bin Lee^*

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

Abstract

Seasonal and novel influenza infections have caused worldwide pandemic. In order to properly treat the infected patients, a rapid and accurate influenza diagnostic tool should be developed. This study therefore presented a new integrated microfluidic system for detection of influenza infection. It integrated a suction-type, pneumatic-driven microfluidic control module, a magnetic bead-based fluorescent immunoassay (FIA) and an end-point optical detection module. This new system could successfully distinguish the influenza A and B within 15 minutes, respectively. Furthermore, the results from 40 patient specimens have concluded that 75% sensitivity and 75% specificity in both positive and negative detections. This developed system would provide a powerful platform for fast screening of influenza infection. Copyright © (2011) by the Chemical and Biological Microsystems Society.

Original language	English
Title of host publication	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages	509-511
Volume	1
Publication status	Published - 2011
Externally published	Yes
Event	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, µTAS 2011 - Washington State Convention Center, Seattle, United States Duration: 2 Oct 2011 → 6 Oct 2011 https://microtasconferences.org/microtas2011/ https://archive.cbmsociety.org/utas/uTAS2011.zip

Publication series

Name	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume	1

Conference

Conference	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, µTAS 2011
Place	United States
City	Seattle
Period	2/10/11 → 6/10/11
Internet address	https://microtasconferences.org/microtas2011/ https://archive.cbmsociety.org/utas/uTAS2011.zip

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Influenza
Microfluidics
Rapid diagnosis

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Huang, T.-B., Hung, L.-Y., Tsai, Y.-C., Yeh, C.-S., Lei, H.-Y., & Lee, G.-B. (2011). Suction-type microfluidic immunomagnetic bead-based system for rapid detection of influenza infection. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (Vol. 1, pp. 509-511). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 1).

Huang, Tze-Bin ; Hung, Lien-Yu ; Tsai, Yi-Che et al. / Suction-type microfluidic immunomagnetic bead-based system for rapid detection of influenza infection. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 1 2011. pp. 509-511 (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011).

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title = "Suction-type microfluidic immunomagnetic bead-based system for rapid detection of influenza infection",

abstract = "Seasonal and novel influenza infections have caused worldwide pandemic. In order to properly treat the infected patients, a rapid and accurate influenza diagnostic tool should be developed. This study therefore presented a new integrated microfluidic system for detection of influenza infection. It integrated a suction-type, pneumatic-driven microfluidic control module, a magnetic bead-based fluorescent immunoassay (FIA) and an end-point optical detection module. This new system could successfully distinguish the influenza A and B within 15 minutes, respectively. Furthermore, the results from 40 patient specimens have concluded that 75\% sensitivity and 75\% specificity in both positive and negative detections. This developed system would provide a powerful platform for fast screening of influenza infection. Copyright {\textcopyright} (2011) by the Chemical and Biological Microsystems Society.",

keywords = "Influenza, Microfluidics, Rapid diagnosis",

author = "Tze-Bin Huang and Lien-Yu Hung and Yi-Che Tsai and Chen-Sheng Yeh and Huan-Yao Lei and Gwo-Bin Lee",

note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].; 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, µTAS 2011 ; Conference date: 02-10-2011 Through 06-10-2011",

year = "2011",

language = "English",

isbn = "9781618395955",

volume = "1",

series = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",

pages = "509--511",

booktitle = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",

url = "https://microtasconferences.org/microtas2011/, https://archive.cbmsociety.org/utas/uTAS2011.zip",

}

Huang, T-B, Hung, L-Y, Tsai, Y-C, Yeh, C-S, Lei, H-Y & Lee, G-B 2011, Suction-type microfluidic immunomagnetic bead-based system for rapid detection of influenza infection. in 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. vol. 1, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, vol. 1, pp. 509-511, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, µTAS 2011, Seattle, Washington, United States, 2/10/11.

Suction-type microfluidic immunomagnetic bead-based system for rapid detection of influenza infection. / Huang, Tze-Bin; Hung, Lien-Yu; Tsai, Yi-Che et al.
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 1 2011. p. 509-511 (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 1).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - Suction-type microfluidic immunomagnetic bead-based system for rapid detection of influenza infection

AU - Huang, Tze-Bin

AU - Hung, Lien-Yu

AU - Tsai, Yi-Che

AU - Yeh, Chen-Sheng

AU - Lei, Huan-Yao

AU - Lee, Gwo-Bin

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2011

Y1 - 2011

N2 - Seasonal and novel influenza infections have caused worldwide pandemic. In order to properly treat the infected patients, a rapid and accurate influenza diagnostic tool should be developed. This study therefore presented a new integrated microfluidic system for detection of influenza infection. It integrated a suction-type, pneumatic-driven microfluidic control module, a magnetic bead-based fluorescent immunoassay (FIA) and an end-point optical detection module. This new system could successfully distinguish the influenza A and B within 15 minutes, respectively. Furthermore, the results from 40 patient specimens have concluded that 75% sensitivity and 75% specificity in both positive and negative detections. This developed system would provide a powerful platform for fast screening of influenza infection. Copyright © (2011) by the Chemical and Biological Microsystems Society.

AB - Seasonal and novel influenza infections have caused worldwide pandemic. In order to properly treat the infected patients, a rapid and accurate influenza diagnostic tool should be developed. This study therefore presented a new integrated microfluidic system for detection of influenza infection. It integrated a suction-type, pneumatic-driven microfluidic control module, a magnetic bead-based fluorescent immunoassay (FIA) and an end-point optical detection module. This new system could successfully distinguish the influenza A and B within 15 minutes, respectively. Furthermore, the results from 40 patient specimens have concluded that 75% sensitivity and 75% specificity in both positive and negative detections. This developed system would provide a powerful platform for fast screening of influenza infection. Copyright © (2011) by the Chemical and Biological Microsystems Society.

KW - Influenza

KW - Microfluidics

KW - Rapid diagnosis

UR - https://www.scopus.com/pages/publications/84883825123

UR - https://www.scopus.com/pages/publications/84883825123#tab=impact

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781618395955

VL - 1

T3 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011

SP - 509

EP - 511

BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011

T2 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, µTAS 2011

Y2 - 2 October 2011 through 6 October 2011

ER -

Huang TB, Hung LY, Tsai YC, Yeh CS, Lei HY, Lee GB. Suction-type microfluidic immunomagnetic bead-based system for rapid detection of influenza infection. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 1. 2011. p. 509-511. (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011).

Suction-type microfluidic immunomagnetic bead-based system for rapid detection of influenza infection

Abstract

Publication series

Conference

Bibliographical note

UN SDGs

Research Keywords

Other Access Options

Permanent Link

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Cite this