Study of influence of catechins on bystander responses in alpha-particle radiobiological experiments using thin PADC films

Y. L. Law; K. N. Yu

doi:10.1016/j.radmeas.2009.10.030

Author(s)

Y. L. Law
K. N. Yu

Detail(s)

Original language	English
Pages (from-to)	1069-1072
Journal / Publication	Radiation Measurements
Volume	44
Issue number	9-10
Publication status	Published - Oct 2009

Link(s)

DOI	DOI https://doi.org/10.1016/j.radmeas.2009.10.030 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-70949101114&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(cf112b33-389a-4c74-80e7-67cef4f108f6).html

Abstract

In this study, Chinese hamster ovary (CHO) cells were cultured in custom-made petri dishes with thin PADC films as substrates. Alpha particles with energies of 5 MeV were then irradiated from the bottom of PADC films. The DNA strand breaks in the bystander cells induced by irradiation were quantified with the use of terminal dUTP transferase-mediated nick end-labeling (TUNEL) assay. To study the influence of catechins on the bystander responses, catechins were added into the medium before alpha-particle irradiation of the cells. Fewer DNA strand breaks in the bystander cells were observed. As catechins are ROS (reactive oxygen species)-scavengers, the studied bystander cells might have been protected from radiation through scavenging of ROS by catechins. © 2009 Elsevier Ltd. All rights reserved.

Research Area(s)

Alpha-particle, Bystander effect, Catechins, TUNEL

Citation Format(s)

[ RIS ] [ BibTeX ]

Study of influence of catechins on bystander responses in alpha-particle radiobiological experiments using thin PADC films. / Law, Y. L.; Yu, K. N.
In: Radiation Measurements, Vol. 44, No. 9-10, 10.2009, p. 1069-1072.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Law, YL & Yu, KN 2009, 'Study of influence of catechins on bystander responses in alpha-particle radiobiological experiments using thin PADC films', Radiation Measurements, vol. 44, no. 9-10, pp. 1069-1072. https://doi.org/10.1016/j.radmeas.2009.10.030

Law, Y. L., & Yu, K. N. (2009). Study of influence of catechins on bystander responses in alpha-particle radiobiological experiments using thin PADC films. Radiation Measurements, 44(9-10), 1069-1072. https://doi.org/10.1016/j.radmeas.2009.10.030

Law YL, Yu KN. Study of influence of catechins on bystander responses in alpha-particle radiobiological experiments using thin PADC films. Radiation Measurements. 2009 Oct;44(9-10):1069-1072. doi: 10.1016/j.radmeas.2009.10.030

Law, Y. L. ; Yu, K. N. / Study of influence of catechins on bystander responses in alpha-particle radiobiological experiments using thin PADC films. In: Radiation Measurements. 2009 ; Vol. 44, No. 9-10. pp. 1069-1072.