Abstract
Phospholamban is a 52-amino-acid protein that assembles into a pentamer in sarcoplasmic reticulum membranes. The protein has a role in the regulation of the resident calcium ATPase through an inhibitory association that can be reversed by phosphorylation. The phosphorylation of phospholamban is initiated by β-adrenergic stimulation, identifying phospholamban as an important component in the stimulation of cardiac activity by β-agonists. It is this role of phospholamban that has motivated studies in recent decades. There is evidence that phospholamban may also function as a Ca2+-selective ion channel. The structural properties of phospholamban have been studied by mutagenesis, modeling, and spectroscopy, resulting in a new view of the organization of this key molecule in membranes.
| Original language | English |
|---|---|
| Pages (from-to) | 157-179 |
| Journal | Annual Review of Biophysics and Biomolecular Structure |
| Volume | 26 |
| DOIs | |
| Publication status | Published - 1997 |
| Externally published | Yes |
Bibliographical note
Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].Research Keywords
- Calcium regulation
- Ion channel
- Membrane protein
- Sarcoplasmic reticulum
- Transmembrane helices
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