Structural Diversification of Andiconin-Derived Natural Products by α-Ketoglutarate-Dependent Dioxygenases

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Tongxuan Bai
  • Hui Tao
  • Takahiro Mori
  • Yonghui Zhang
  • Ikuro Abe

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)4311-4315
Number of pages5
Journal / PublicationOrganic Letters
Volume22
Issue number11
Online published13 May 2020
Publication statusPublished - 5 Jun 2020

Abstract

The biosynthetic gene cluster of the fungal meroterpenoid emeridone F (8) was discovered in the genome of Aspergillus sp. TJ23, and its late-stage biosynthesis was elucidated by characterizing two α-ketoglutarate (αKG)-dependent dioxygenases, SptF and SptN. SptF catalyzes oxidative rearrangement followed by epoxidation, whereas SptN serves as the C-9 hydroxylase. Our study provides insight into the biosynthetic mechanisms of other andiconin (1)-derived natural products, exemplifying the important roles of αKG-dependent enzymes in the structural complexifications.

Citation Format(s)

Structural Diversification of Andiconin-Derived Natural Products by α-Ketoglutarate-Dependent Dioxygenases. / Bai, Tongxuan; Matsuda, Yudai; Tao, Hui; Mori, Takahiro; Zhang, Yonghui; Abe, Ikuro.

In: Organic Letters, Vol. 22, No. 11, 05.06.2020, p. 4311-4315.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review