Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

6 Scopus Citations
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Author(s)

  • Ka Lung Chan
  • Chun-Yin Chan
  • Aleksandr B. Sahakyan

Detail(s)

Original languageEnglish
Pages (from-to)10878-10881
Journal / PublicationChemical communications (Cambridge, England)
Volume54
Issue number77
Online published27 Aug 2018
Publication statusPublished - 4 Oct 2018

Abstract

Here we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA-mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in miRNAs. Notably, we study the effect of these rG4s in cells and uncover the role of rG4s in miRNA-mediated post-transcriptional regulation.

Citation Format(s)

Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs. / Chan, Ka Lung; Peng, Boya; Umar, Mubarak I.; Chan, Chun-Yin; Sahakyan, Aleksandr B.; Le, Minh T. N.; Kwok, Chun Kit.

In: Chemical communications (Cambridge, England), Vol. 54, No. 77, 04.10.2018, p. 10878-10881.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review