Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs

Ka Lung Chan; Boya Peng; Mubarak I. Umar; Chun-Yin Chan; Aleksandr B. Sahakyan; Minh T. N. Le; Chun Kit Kwok

doi:10.1039/c8cc04635b

Author(s)

Ka Lung Chan
Chun-Yin Chan
Aleksandr B. Sahakyan

Related Research Unit(s)

Detail(s)

Original language	English
Pages (from-to)	10878-10881
Journal / Publication	Chemical communications (Cambridge, England)
Volume	54
Issue number	77
Online published	27 Aug 2018
Publication status	Published - 4 Oct 2018

Link(s)

DOI	DOI https://doi.org/10.1039/c8cc04635b Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85053921329&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(72815a6e-f5b4-4cc4-b9c9-ee1baef78061).html

Abstract

Here we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA-mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in miRNAs. Notably, we study the effect of these rG4s in cells and uncover the role of rG4s in miRNA-mediated post-transcriptional regulation.

Citation Format(s)

[ RIS ] [ BibTeX ]

Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs. / Chan, Ka Lung; Peng, Boya ; Umar, Mubarak I. et al.
In: Chemical communications (Cambridge, England), Vol. 54, No. 77, 04.10.2018, p. 10878-10881.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Chan, KL, Peng, B , Umar, MI, Chan, C-Y, Sahakyan, AB, Le, MTN & Kwok, CK 2018, 'Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs', Chemical communications (Cambridge, England), vol. 54, no. 77, pp. 10878-10881. https://doi.org/10.1039/c8cc04635b

Chan, K. L., Peng, B., Umar, M. I., Chan, C.-Y., Sahakyan, A. B., Le, M. T. N., & Kwok, C. K. (2018). Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs. Chemical communications (Cambridge, England), 54(77), 10878-10881. https://doi.org/10.1039/c8cc04635b

Chan KL, Peng B , Umar MI, Chan CY, Sahakyan AB, Le MTN et al. Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs. Chemical communications (Cambridge, England). 2018 Oct 4;54(77):10878-10881. Epub 2018 Aug 27. doi: 10.1039/c8cc04635b

Chan, Ka Lung ; Peng, Boya ; Umar, Mubarak I. et al. / Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs. In: Chemical communications (Cambridge, England). 2018 ; Vol. 54, No. 77. pp. 10878-10881.