Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs

Ka Lung Chan; Boya Peng; Mubarak I. Umar; Chun-Yin Chan; Aleksandr B. Sahakyan; Minh T. N. Le; Chun Kit Kwok

doi:10.1039/c8cc04635b

Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs

Ka Lung Chan
, Boya Peng
, Mubarak I. Umar
, Chun-Yin Chan
, Aleksandr B. Sahakyan
, Minh T. N. Le^*
, Chun Kit Kwok^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

40 Citations (Scopus)

Abstract

Here we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA-mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in miRNAs. Notably, we study the effect of these rG4s in cells and uncover the role of rG4s in miRNA-mediated post-transcriptional regulation.

Original language	English
Pages (from-to)	10878-10881
Journal	Chemical communications (Cambridge, England)
Volume	54
Issue number	77
Online published	27 Aug 2018
DOIs	https://doi.org/10.1039/c8cc04635b
Publication status	Published - 4 Oct 2018

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title = "Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs",

abstract = "Here we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA-mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in miRNAs. Notably, we study the effect of these rG4s in cells and uncover the role of rG4s in miRNA-mediated post-transcriptional regulation.",

author = "Chan, \{Ka Lung\} and Boya Peng and Umar, \{Mubarak I.\} and Chun-Yin Chan and Sahakyan, \{Aleksandr B.\} and Le, \{Minh T. N.\} and Kwok, \{Chun Kit\}",

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T1 - Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs

AU - Chan, Ka Lung

AU - Peng, Boya

AU - Umar, Mubarak I.

AU - Chan, Chun-Yin

AU - Sahakyan, Aleksandr B.

AU - Le, Minh T. N.

AU - Kwok, Chun Kit

PY - 2018/10/4

Y1 - 2018/10/4

N2 - Here we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA-mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in miRNAs. Notably, we study the effect of these rG4s in cells and uncover the role of rG4s in miRNA-mediated post-transcriptional regulation.

AB - Here we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA-mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in miRNAs. Notably, we study the effect of these rG4s in cells and uncover the role of rG4s in miRNA-mediated post-transcriptional regulation.

UR - https://www.scopus.com/pages/publications/85053921329

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85053921329&origin=recordpage

U2 - 10.1039/c8cc04635b

DO - 10.1039/c8cc04635b

M3 - RGC 21 - Publication in refereed journal

C2 - 30204160

SN - 0009-241X

VL - 54

SP - 10878

EP - 10881

JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

IS - 77

ER -

Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs

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