Strategic Design of Luminescent Rhenium(I), Ruthenium(II), and Iridium(III) Complexes as Activity-Based Probes for Bioimaging and Biosensing

Lawrence Cho-Cheung Lee; Kenneth Kam-Wing Lo

doi:10.1002/asia.202200840

Strategic Design of Luminescent Rhenium(I), Ruthenium(II), and Iridium(III) Complexes as Activity-Based Probes for Bioimaging and Biosensing

Lawrence Cho-Cheung Lee, Kenneth Kam-Wing Lo^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

33 Citations (Scopus)

99 Downloads (CityUHK Scholars)

Abstract

The rapid development of responsive fluorescent probes has advanced optical imaging for biological research and biomedical applications. Among different sensing strategies, activity-based sensing, which exploits the unique reactivity of the target chemical species to achieve high chemoselectivity, has emerged as a promising paradigm for the development of responsive probes for selective molecular imaging. Luminescent transition metal complexes have received considerable attention for bioimaging and biosensing applications over the last decade due to their remarkable photophysical behavior including intense emission with large Stokes’ shifts, long emission lifetimes, strong two-photon absorption, and high photostability. In this Review, we summarize the design strategies and applications of luminescent complexes of rhenium(I), ruthenium(II), and iridium(III) polypyridines as activity-based probes for the detection of various chemical species and bioactive molecules in live cells and organisms. The current challenges and future prospects of these complexes as activatable reagents for disease diagnosis and treatment are also discussed.

Original language	English
Article number	e202200840
Journal	Chemistry—An Asian Journal
Volume	17
Issue number	22
Online published	21 Sept 2022
DOIs	https://doi.org/10.1002/asia.202200840
Publication status	Published - 16 Nov 2022

Funding

We thank the Hong Kong Research Grants Council (Project No. CityU 11300019, CityU 11302820, CityU 11301121, T42-103/16- N, C6014-20W, C7075-21GF, and N_CityU104/21) for financial support. We also acknowledge the funding support from “Laboratory for Synthetic Chemistry and Chemical Biology” under the Health@InnoHK Program launched by Innovation and Technology Commission, The Government of Hong Kong SAR, P. R. China.

Research Keywords

activity-based sensing
biosensors
diagnostics
imaging agents
luminescence
phosphorogenic
transition metal complexes

Publisher's Copyright Statement

COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This is the peer reviewed version of the following article: Lee, L. C-C., & Lo, K. K-W. (2022). Strategic Design of Luminescent Rhenium(I), Ruthenium(II), and Iridium(III) Complexes as Activity-Based Probes for Bioimaging and Biosensing. Chemistry—An Asian Journal, 17(22), [e202200840], which has been published in final form at https://doi.org/10.1002/asia.202200840.
This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

RGC Funding Information

RGC-funded

Access Output

10.1002/asia.202200840

122434389.pdfPost-print, 1.96 MB

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

@article{b3d2f110e5f4400b918bfc218f2dc20d,

title = "Strategic Design of Luminescent Rhenium(I), Ruthenium(II), and Iridium(III) Complexes as Activity-Based Probes for Bioimaging and Biosensing",

abstract = "The rapid development of responsive fluorescent probes has advanced optical imaging for biological research and biomedical applications. Among different sensing strategies, activity-based sensing, which exploits the unique reactivity of the target chemical species to achieve high chemoselectivity, has emerged as a promising paradigm for the development of responsive probes for selective molecular imaging. Luminescent transition metal complexes have received considerable attention for bioimaging and biosensing applications over the last decade due to their remarkable photophysical behavior including intense emission with large Stokes{\textquoteright} shifts, long emission lifetimes, strong two-photon absorption, and high photostability. In this Review, we summarize the design strategies and applications of luminescent complexes of rhenium(I), ruthenium(II), and iridium(III) polypyridines as activity-based probes for the detection of various chemical species and bioactive molecules in live cells and organisms. The current challenges and future prospects of these complexes as activatable reagents for disease diagnosis and treatment are also discussed.",

keywords = "activity-based sensing, biosensors, diagnostics, imaging agents, luminescence, phosphorogenic, transition metal complexes",

author = "Lee, {Lawrence Cho-Cheung} and Lo, {Kenneth Kam-Wing}",

year = "2022",

month = nov,

day = "16",

doi = "10.1002/asia.202200840",

language = "English",

volume = "17",

journal = "Chemistry—An Asian Journal",

issn = "1861-4728",

publisher = "John Wiley & Sons",

number = "22",

}

Strategic Design of Luminescent Rhenium(I), Ruthenium(II), and Iridium(III) Complexes as Activity-Based Probes for Bioimaging and Biosensing. / Lee, Lawrence Cho-Cheung ; Lo, Kenneth Kam-Wing.
In: Chemistry—An Asian Journal, Vol. 17, No. 22, e202200840, 16.11.2022.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Strategic Design of Luminescent Rhenium(I), Ruthenium(II), and Iridium(III) Complexes as Activity-Based Probes for Bioimaging and Biosensing

AU - Lee, Lawrence Cho-Cheung

AU - Lo, Kenneth Kam-Wing

PY - 2022/11/16

Y1 - 2022/11/16

N2 - The rapid development of responsive fluorescent probes has advanced optical imaging for biological research and biomedical applications. Among different sensing strategies, activity-based sensing, which exploits the unique reactivity of the target chemical species to achieve high chemoselectivity, has emerged as a promising paradigm for the development of responsive probes for selective molecular imaging. Luminescent transition metal complexes have received considerable attention for bioimaging and biosensing applications over the last decade due to their remarkable photophysical behavior including intense emission with large Stokes’ shifts, long emission lifetimes, strong two-photon absorption, and high photostability. In this Review, we summarize the design strategies and applications of luminescent complexes of rhenium(I), ruthenium(II), and iridium(III) polypyridines as activity-based probes for the detection of various chemical species and bioactive molecules in live cells and organisms. The current challenges and future prospects of these complexes as activatable reagents for disease diagnosis and treatment are also discussed.

AB - The rapid development of responsive fluorescent probes has advanced optical imaging for biological research and biomedical applications. Among different sensing strategies, activity-based sensing, which exploits the unique reactivity of the target chemical species to achieve high chemoselectivity, has emerged as a promising paradigm for the development of responsive probes for selective molecular imaging. Luminescent transition metal complexes have received considerable attention for bioimaging and biosensing applications over the last decade due to their remarkable photophysical behavior including intense emission with large Stokes’ shifts, long emission lifetimes, strong two-photon absorption, and high photostability. In this Review, we summarize the design strategies and applications of luminescent complexes of rhenium(I), ruthenium(II), and iridium(III) polypyridines as activity-based probes for the detection of various chemical species and bioactive molecules in live cells and organisms. The current challenges and future prospects of these complexes as activatable reagents for disease diagnosis and treatment are also discussed.

KW - activity-based sensing

KW - biosensors

KW - diagnostics

KW - imaging agents

KW - luminescence

KW - phosphorogenic

KW - transition metal complexes

UR - http://www.scopus.com/inward/record.url?scp=85139939574&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85139939574&origin=recordpage

U2 - 10.1002/asia.202200840

DO - 10.1002/asia.202200840

M3 - RGC 21 - Publication in refereed journal

SN - 1861-4728

VL - 17

JO - Chemistry—An Asian Journal

JF - Chemistry—An Asian Journal

IS - 22

M1 - e202200840

ER -

Strategic Design of Luminescent Rhenium(I), Ruthenium(II), and Iridium(III) Complexes as Activity-Based Probes for Bioimaging and Biosensing

Abstract

Funding

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

NSFC: Design and Preparation of Phosphorescent Lifetime-Responsive Polymeric Probes for Enzyme Targeting and Catalytic Activity Sensing in Living Cells

GRF: Modulation of the Luminescence Properties and Photocytotoxic Activity of Transition Metal Complexes through Dissociative Bioorthogonal Reactions for Diagnostic and Therapeutic Applications

CRF-ExtU-Lead: New Aggregation-Induced Emission Systems: Solving the Existing Problems in Bioimaging and Developing New Biological Applications

Cite this

Strategic Design of Luminescent Rhenium(I), Ruthenium(II), and Iridium(III) Complexes as Activity-Based Probes for Bioimaging and Biosensing

Abstract

Funding

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Projects

NSFC: Design and Preparation of Phosphorescent Lifetime-Responsive Polymeric Probes for Enzyme Targeting and Catalytic Activity Sensing in Living Cells

GRF: Modulation of the Luminescence Properties and Photocytotoxic Activity of Transition Metal Complexes through Dissociative Bioorthogonal Reactions for Diagnostic and Therapeutic Applications

CRF-ExtU-Lead: New Aggregation-Induced Emission Systems: Solving the Existing Problems in Bioimaging and Developing New Biological Applications

Cite this