Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α

Wei Zhao; Cunjie Chang; Yangyan Cui; Xiaozhi Zhao; Jun Yang; Lan Shen; Ji Zhou; Zhibo Hou; Zhen Zhang; Changxiao Ye; Donald Hasenmayer; Robert Perkins; Xiaojing Huang; Xin Yao; Like Yu; Ruimin Huang; Dianzheng Zhang; Hongqian Guo; Jun Yan

doi:10.1074/jbc.M113.535989

Author(s)

Wei Zhao
Cunjie Chang
Yangyan Cui
Xiaozhi Zhao
Jun Yang
And 14 others

Lan Shen
Ji Zhou
Zhibo Hou
Zhen Zhang
Changxiao Ye
Donald Hasenmayer
Robert Perkins
Xiaojing Huang
Xin Yao
Like Yu
Ruimin Huang
Dianzheng Zhang
Hongqian Guo
Jun Yan

Detail(s)

Original language	English
Pages (from-to)	11219-11229
Journal / Publication	Journal of Biological Chemistry
Volume	289
Issue number	16
Publication status	Published - 18 Apr 2014
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1074/jbc.M113.535989 Final Published version
	Check@CityULib
Attachment(s)	Documents 73264951.pdf Final Published version, 2.12 MB, PDF Publisher's Copyright Statement This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-84899021999&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(62db60f2-ac27-48ad-8e93-48f815562435).html

Abstract

Background: Steroid receptor coactivator-3 (SRC-3) is frequently overexpressed in human urinary bladder cancer. Results: SRC-3 promotes urinary bladder cancer (UBC) cells proliferation through coactivating HIF1 and up-regulating the expression of genes involved in the glycolytic pathway. Conclusion: SRC-3 plays an important role in UBC development through enhancing glycolysis. Significance: Targeting SRC-3 or enzymes in glycolytic pathway could be an attractive approach in UBC therapy. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Research Area(s)

SDG 3 - Good Health and Well-being

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Citation Format(s)

[ RIS ] [ BibTeX ]

Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α. / Zhao, Wei; Chang, Cunjie; Cui, Yangyan et al.
In: Journal of Biological Chemistry, Vol. 289, No. 16, 18.04.2014, p. 11219-11229.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Zhao, W, Chang, C, Cui, Y, Zhao, X, Yang, J, Shen, L, Zhou, J, Hou, Z, Zhang, Z, Ye, C, Hasenmayer, D, Perkins, R, Huang, X, Yao, X, Yu, L, Huang, R, Zhang, D, Guo, H & Yan, J 2014, 'Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α', Journal of Biological Chemistry, vol. 289, no. 16, pp. 11219-11229. https://doi.org/10.1074/jbc.M113.535989

Zhao, W., Chang, C., Cui, Y., Zhao, X., Yang, J., Shen, L., Zhou, J., Hou, Z., Zhang, Z., Ye, C., Hasenmayer, D., Perkins, R., Huang, X., Yao, X., Yu, L., Huang, R., Zhang, D., Guo, H., & Yan, J. (2014). Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α. Journal of Biological Chemistry, 289(16), 11219-11229. https://doi.org/10.1074/jbc.M113.535989

Zhao W, Chang C, Cui Y, Zhao X, Yang J, Shen L et al. Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α. Journal of Biological Chemistry. 2014 Apr 18;289(16):11219-11229. doi: 10.1074/jbc.M113.535989

Zhao, Wei ; Chang, Cunjie ; Cui, Yangyan et al. / Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 16. pp. 11219-11229.

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