Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α

Wei Zhao; Cunjie Chang; Yangyan Cui; Xiaozhi Zhao; Jun Yang; Lan Shen; Ji Zhou; Zhibo Hou; Zhen Zhang; Changxiao Ye; Donald Hasenmayer; Robert Perkins; Xiaojing Huang; Xin Yao; Like Yu; Ruimin Huang; Dianzheng Zhang; Hongqian Guo; Jun Yan

doi:10.1074/jbc.M113.535989

Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α

Wei Zhao, Cunjie Chang, Yangyan Cui, Xiaozhi Zhao, Jun Yang, Lan Shen, Ji Zhou, Zhibo Hou, Zhen Zhang, Changxiao Ye, Donald Hasenmayer, Robert Perkins, Xiaojing Huang, Xin Yao, Like Yu, Ruimin Huang, Dianzheng Zhang, Hongqian Guo, Jun Yan

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

55 Citations (Scopus)

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Abstract

Background: Steroid receptor coactivator-3 (SRC-3) is frequently overexpressed in human urinary bladder cancer. Results: SRC-3 promotes urinary bladder cancer (UBC) cells proliferation through coactivating HIF1 and up-regulating the expression of genes involved in the glycolytic pathway. Conclusion: SRC-3 plays an important role in UBC development through enhancing glycolysis. Significance: Targeting SRC-3 or enzymes in glycolytic pathway could be an attractive approach in UBC therapy. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Original language	English
Pages (from-to)	11219-11229
Journal	Journal of Biological Chemistry
Volume	289
Issue number	16
DOIs	https://doi.org/10.1074/jbc.M113.535989
Publication status	Published - 18 Apr 2014
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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Zhao, W., Chang, C., Cui, Y., Zhao, X., Yang, J., Shen, L., Zhou, J., Hou, Z., Zhang, Z., Ye, C., Hasenmayer, D., Perkins, R., Huang, X., Yao, X., Yu, L., Huang, R., Zhang, D., Guo, H., & Yan, J. (2014). Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α. Journal of Biological Chemistry, 289(16), 11219-11229. https://doi.org/10.1074/jbc.M113.535989

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title = "Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α",

abstract = "Background: Steroid receptor coactivator-3 (SRC-3) is frequently overexpressed in human urinary bladder cancer. Results: SRC-3 promotes urinary bladder cancer (UBC) cells proliferation through coactivating HIF1 and up-regulating the expression of genes involved in the glycolytic pathway. Conclusion: SRC-3 plays an important role in UBC development through enhancing glycolysis. Significance: Targeting SRC-3 or enzymes in glycolytic pathway could be an attractive approach in UBC therapy. {\textcopyright} 2014 by The American Society for Biochemistry and Molecular Biology, Inc.",

author = "Wei Zhao and Cunjie Chang and Yangyan Cui and Xiaozhi Zhao and Jun Yang and Lan Shen and Ji Zhou and Zhibo Hou and Zhen Zhang and Changxiao Ye and Donald Hasenmayer and Robert Perkins and Xiaojing Huang and Xin Yao and Like Yu and Ruimin Huang and Dianzheng Zhang and Hongqian Guo and Jun Yan",

note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].",

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doi = "10.1074/jbc.M113.535989",

language = "English",

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Zhao, W, Chang, C, Cui, Y, Zhao, X, Yang, J, Shen, L, Zhou, J, Hou, Z, Zhang, Z, Ye, C, Hasenmayer, D, Perkins, R, Huang, X, Yao, X, Yu, L, Huang, R, Zhang, D, Guo, H & Yan, J 2014, 'Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α', Journal of Biological Chemistry, vol. 289, no. 16, pp. 11219-11229. https://doi.org/10.1074/jbc.M113.535989

Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α. / Zhao, Wei; Chang, Cunjie; Cui, Yangyan et al.
In: Journal of Biological Chemistry, Vol. 289, No. 16, 18.04.2014, p. 11219-11229.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α

AU - Zhao, Wei

AU - Chang, Cunjie

AU - Cui, Yangyan

AU - Zhao, Xiaozhi

AU - Yang, Jun

AU - Shen, Lan

AU - Zhou, Ji

AU - Hou, Zhibo

AU - Zhang, Zhen

AU - Ye, Changxiao

AU - Hasenmayer, Donald

AU - Perkins, Robert

AU - Huang, Xiaojing

AU - Yao, Xin

AU - Yu, Like

AU - Huang, Ruimin

AU - Zhang, Dianzheng

AU - Guo, Hongqian

AU - Yan, Jun

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PY - 2014/4/18

Y1 - 2014/4/18

N2 - Background: Steroid receptor coactivator-3 (SRC-3) is frequently overexpressed in human urinary bladder cancer. Results: SRC-3 promotes urinary bladder cancer (UBC) cells proliferation through coactivating HIF1 and up-regulating the expression of genes involved in the glycolytic pathway. Conclusion: SRC-3 plays an important role in UBC development through enhancing glycolysis. Significance: Targeting SRC-3 or enzymes in glycolytic pathway could be an attractive approach in UBC therapy. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

AB - Background: Steroid receptor coactivator-3 (SRC-3) is frequently overexpressed in human urinary bladder cancer. Results: SRC-3 promotes urinary bladder cancer (UBC) cells proliferation through coactivating HIF1 and up-regulating the expression of genes involved in the glycolytic pathway. Conclusion: SRC-3 plays an important role in UBC development through enhancing glycolysis. Significance: Targeting SRC-3 or enzymes in glycolytic pathway could be an attractive approach in UBC therapy. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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JO - Journal of Biological Chemistry

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Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α

Abstract

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