Stepwise Ligand-induced Self-assembly for Facile Fabrication of Nanodiamond-Gold Nanoparticle Dimers via Noncovalent Biotin-Streptavidin Interactions

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

View graph of relations

Author(s)

  • Renate Landig
  • Joonhee Choi
  • Hengyun Zhou
  • Xing Liao
  • Mikhail D. Lukin
  • Hongkun Park

Detail(s)

Original languageEnglish
Pages (from-to)2020-2026
Journal / PublicationNano Letters
Volume19
Issue number3
Early online date19 Feb 2019
Publication statusPublished - 13 Mar 2019

Abstract

Nanodiamond-gold nanoparticle (ND-AuNP) dimers constitute a potent tool for controlled thermal heating of biological systems on the nanoscale, by combining a local light-induced heat source with a sensitive local thermometer. Unfortunately, previous solution-based strategies to build ND-AuNP conjugates resulted in large nanoclusters or a broad population of multimers with limited separation efficiency. Here, we describe a new strategy to synthesize discrete ND-AuNP dimers via the synthesis of biotin-labeled DNA-AuNPs through thiol chemistry and its immobilization onto the magnetic bead (MB) surface, followed by reacting with streptavidin-labeled NDs. The dimers can be easily released from MB via a strand displacement reaction and separated magnetically. Our method is facile, convenient, and scalable, ensuring high-throughput formation of very stable dimer structures. This ligand-induced self-assembly approach enables the preparation of a wide variety of dimers of designated sizes and compositions, thus opening up the possibility that they can be deployed in many biological actuation and sensing applications.

Research Area(s)

  • biotin-streptavidin interactions, dual-functional, gold nanoparticle, nanodiamond, particle dimers

Citation Format(s)

Stepwise Ligand-induced Self-assembly for Facile Fabrication of Nanodiamond-Gold Nanoparticle Dimers via Noncovalent Biotin-Streptavidin Interactions. / Chan, Miu Shan; Landig, Renate; Choi, Joonhee; Zhou, Hengyun; Liao, Xing; Lukin, Mikhail D.; Park, Hongkun; Lo, Pik Kwan.

In: Nano Letters, Vol. 19, No. 3, 13.03.2019, p. 2020-2026.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review