Stepwise 3D-spatio-temporal magnesium cationic niche : Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

3 Scopus Citations
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Author(s)

  • Jie Shen
  • Bo Chen
  • Xinyun Zhai
  • Wei Qiao
  • Shuilin Wu
  • Xuanyong Liu
  • Ying Zhao
  • Changshun Ruan
  • Haobo Pan
  • Kenneth M.C. Cheung
  • Kelvin W.K. Yeung

Detail(s)

Original languageEnglish
Pages (from-to)503-519
Journal / PublicationBioactive Materials
Volume6
Issue number2
Online published10 Sep 2020
Publication statusPublished - Feb 2021

Link(s)

Abstract

The fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chemical, biological, or physical cues within a local tissue microenvironment. Deeper understanding of how mammalian cells react to local tissue microenvironment is paramount important when designing next generation of biomaterials for tissue engineering. This study aims to investigate that the regulation of magnesium cationic (Mg2+) tissue microenvironment is able to convince early-stage bone regeneration and its mechanism undergoes intramembranous ossification. It was discovered that moderate Mg2+ content niche (~4.11 mM) led to superior bone regeneration, while Mg2+-free and strong Mg2+ content (~16.44 mM) discouraged cell adhesion, proliferation and osteogenic differentiation, thereby bone formation was rarely found. When magnesium ions diffused into free Mg zone from concentrated zone in late time point, new bone formation on free Mg zone became significant through intramembranous ossification. This study successfully demonstrates that magnesium cationic microenvironment serves as an effective biochemical cue and is able to modulate the process of bony tissue regeneration. The knowledge of how a Mg2+ cationic microenvironment intertwines with cells and subsequent bone formation gained from this study may provide a new insight to develop the next generation of tissue-repairing biomaterials.

Research Area(s)

  • 3D scaffold, Bone tissue regeneration, Magnesium ion, Microenvironment, Nanocomposite

Citation Format(s)

Stepwise 3D-spatio-temporal magnesium cationic niche : Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification. / Shen, Jie; Chen, Bo; Zhai, Xinyun; Qiao, Wei; Wu, Shuilin; Liu, Xuanyong; Zhao, Ying; Ruan, Changshun; Pan, Haobo; Chu, Paul K.; Cheung, Kenneth M.C.; Yeung, Kelvin W.K.

In: Bioactive Materials, Vol. 6, No. 2, 02.2021, p. 503-519.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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