TY - JOUR
T1 - Stable π-radical nanoparticles as versatile photosensitizers for effective hypoxia-overcoming photodynamic therapy
AU - Cui, Xiao
AU - Lu, Guihong
AU - Dong, Shengzhi
AU - Li, Shengliang
AU - Xiao, Yafang
AU - Zhang, Jinfeng
AU - Liu, Yanhong
AU - Meng, Xiangmin
AU - Li, Feng
AU - Lee, Chun-Sing
PY - 2021/2/1
Y1 - 2021/2/1
N2 - We report the first demonstration using a stable π-radical as a versatile photosensitizer for hypoxia-overcoming photodynamic therapy. After self-assembling the radical molecules into radical nanoparticles (NPs), the NPs show good water dispersibility, good biocompatibility, broad near-infrared (NIR) absorption and emission at ∼800 nm. Significantly, the radical NPs remain stable in various biological mediums, after 100 days exposure to the ambient environment, and even after long-term laser irradiation, which is superior to many reported radical-based materials. More importantly, upon 635 nm laser irradiation, sufficient superoxide radical (O2−˙) generation and in vitro cytotoxicity were observed addressing the most important hurdle for successful PDT in the oxygen-deficient tumor microenvironment. In addition, the radical NPs are also demonstrated to have effective in vivo PDT efficacy, and excellent biosafety.
AB - We report the first demonstration using a stable π-radical as a versatile photosensitizer for hypoxia-overcoming photodynamic therapy. After self-assembling the radical molecules into radical nanoparticles (NPs), the NPs show good water dispersibility, good biocompatibility, broad near-infrared (NIR) absorption and emission at ∼800 nm. Significantly, the radical NPs remain stable in various biological mediums, after 100 days exposure to the ambient environment, and even after long-term laser irradiation, which is superior to many reported radical-based materials. More importantly, upon 635 nm laser irradiation, sufficient superoxide radical (O2−˙) generation and in vitro cytotoxicity were observed addressing the most important hurdle for successful PDT in the oxygen-deficient tumor microenvironment. In addition, the radical NPs are also demonstrated to have effective in vivo PDT efficacy, and excellent biosafety.
UR - http://www.scopus.com/inward/record.url?scp=85100940883&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85100940883&origin=recordpage
U2 - 10.1039/d0mh01312a
DO - 10.1039/d0mh01312a
M3 - RGC 21 - Publication in refereed journal
SN - 2051-6347
VL - 8
SP - 571
EP - 576
JO - Materials Horizons
JF - Materials Horizons
IS - 2
ER -