Stability of alcohol and tobacco consumption biomarkers in a real rising main sewer

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Jianfa Gao
  • Jiaying Li
  • Guangming Jiang
  • Geoff Eaglesham
  • Adrian Covaci
  • Jochen F. Mueller
  • Phong K. Thai

Detail(s)

Original languageEnglish
Pages (from-to)19-26
Journal / PublicationWater Research
Volume138
Publication statusPublished - 1 Jul 2018
Externally publishedYes

Abstract

Since alcohol and tobacco consumption are among the leading causes of population health harm, it is very important to understand the consumption behaviour to develop effective harm reduction strategies. Wastewater-based epidemiology (WBE) is a potential tool for estimating their consumption, but there are several uncertainties that need to be determined, including the stability of biomarkers in the sewer. Utilizing a real rising main sewer, this study investigated the stability of alcohol and tobacco consumption biomarkers. Rhodamine and acesulfame were used as flow tracer and benchmarker to understand the transportation of wastewater in the sewer with a hydraulic retention time between 2.7 and 5.0 h. Ethyl sulphate (EtS) and ethyl glucuronide (EtG), two biomarkers of alcohol consumption, were found to have different in-sewer stability, with EtS much more stable than EtG. The degradation rate of EtS is approximately 8% per hour, while EtG has a half-life of 1.9 h. Formation of nicotine, cotinine and trans-3′-hydroxycotinine, three biomarkers for tobacco consumption, was observed during the experiment, probably due to deconjugation of their glucuronide chemicals. The deconjugation process has prevented the determination of actual stability of the three chemicals. However, it is suggested that cotinine is relatively stable, while nicotine and trans-3′-hydroxycotinine degrade to a certain degree in the sewer system. According to our findings, the in-sewer degradation is more important during the interpretation of alcohol consumption estimation than for tobacco consumption estimation. © 2018 Elsevier Ltd

Research Area(s)

  • Alcohol and tobacco, Benchmarking, Biomarker stability, LC-MS/MS, Wastewater-based epidemiology

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

Stability of alcohol and tobacco consumption biomarkers in a real rising main sewer. / Gao, Jianfa; Li, Jiaying; Jiang, Guangming et al.
In: Water Research, Vol. 138, 01.07.2018, p. 19-26.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review