TY - GEN
T1 - Stability Analysis of Boolean Networks
T2 - 63rd IEEE Conference on Decision and Control (CDC 2024)
AU - Liu, Aixin
AU - Wang, Lin
AU - Chen, Guanrong
AU - Guan, Xinping
PY - 2024/12
Y1 - 2024/12
N2 - This study investigates the impact of multi-bit function perturbations (MFPs) on the steady-state distribution of Boolean networks (BNs), with a focus on robust stability. First, the algebraic formulation of BNs under MFPs is introduced. Then, a novel stability criterion is proposed, demonstrating that monotonically decreasing perturbations can effectively ensure the stability of BNs against MFPs. A significant advantage of this approach is that it enables robust stability assessment without remodeling the perturbed BNs. Applying this methodology to a simplified Boolean model of the lactose operon in Escherichia coli reveals that MFPs can serve as strategic tools to promote stability within BNs, rather than being merely disruptive. © 2024 IEEE.
AB - This study investigates the impact of multi-bit function perturbations (MFPs) on the steady-state distribution of Boolean networks (BNs), with a focus on robust stability. First, the algebraic formulation of BNs under MFPs is introduced. Then, a novel stability criterion is proposed, demonstrating that monotonically decreasing perturbations can effectively ensure the stability of BNs against MFPs. A significant advantage of this approach is that it enables robust stability assessment without remodeling the perturbed BNs. Applying this methodology to a simplified Boolean model of the lactose operon in Escherichia coli reveals that MFPs can serve as strategic tools to promote stability within BNs, rather than being merely disruptive. © 2024 IEEE.
UR - http://www.scopus.com/inward/record.url?scp=86000594698&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-86000594698&origin=recordpage
U2 - 10.1109/CDC56724.2024.10886778
DO - 10.1109/CDC56724.2024.10886778
M3 - RGC 32 - Refereed conference paper (with host publication)
SN - 979-8-3503-1634-6
T3 - Proceedings of the IEEE Conference on Decision and Control
SP - 2946
EP - 2951
BT - 2024 IEEE 63rd Conference on Decision and Control (CDC)
PB - IEEE
Y2 - 16 December 2024 through 19 December 2024
ER -