Spontaneous Feedforward Connectivity in Electrically Stimulated Retinal Degeneration Mice

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)peer-review

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Detail(s)

Original languageEnglish
Title of host publication42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publication"Enabling Innovative Technologies for Global Healthcare"
PublisherIEEE
Pages3513-3516
ISBN (Electronic)9781728119908
ISBN (Print)9781728119915
Publication statusPublished - Jul 2020

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume2020-July
ISSN (Print)1557-170X
ISSN (Electronic)1558-4615

Conference

Title42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC 2020)
PlaceCanada
CityMontreal
Period20 - 24 July 2020

Abstract

Retinal degeneration (Rd) is a neurodegenerative disorder primarily associated with the degeneration of the retina neurons and culminates in the eventual loss of visual perception or blindness. Decrease in fronto-, parietal and occipital brain connectivity have been reported in a number of neurodegeneration diseases involving cognitive decline. However, cortical communication in the brain of retinal degeneration patients remains largely unknown and strategies to remediate observed dysfunctional brain connectivity in such instance have not be thoroughly investigated. We used rd10 mice as a model to study brain connectivity in the human retinal degeneration disease, retinitis pigmentosa. Rd10 mice with sham matched controls were electrically stimulated at varying stimulation frequencies and the consequent perturbations in feedforward brain connectivity were studied in the visual cortex and pre-frontal cortex using electrocorticography (ECoG) and normalized symbolic transfer entropy (NSTE). Contra Vcx - contra PFx feed forward connectivity significantly (p<0.05) increased in theta, alpha and beta oscillatory bands of 2 Hz and 10 Hz stimulated rd10 respectively in comparison with sham group. Also, this increase was significantly maintained even after the end of the stimulation period.

Citation Format(s)

Spontaneous Feedforward Connectivity in Electrically Stimulated Retinal Degeneration Mice. / Agadagba, Stephen K.; Chan, Leanne L.H.

42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: "Enabling Innovative Technologies for Global Healthcare". IEEE, 2020. p. 3513-3516 9175231 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2020-July).

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)peer-review